SRP3132
Osteoprotegerin (OPG) human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
别名:
OCIF (osteoclastogenesis inhibitory factor), OPG, TNFRSF11B, TR1
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50 μG
$522.00
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50 μG
$522.00
About This Item
UNSPSC代码:
12352202
NACRES:
NA.32
$522.00
请联系客服了解存货情况
新价格，新优惠！
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生物来源
human
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
分子量
20.0 kDa
包装
pkg of 50 μg
技术
cell culture | mammalian: suitable
杂质
<0.1 EU/μg endotoxin, tested
颜色
white to off-white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... TNFRSF11B(4982)
相关类别
一般描述
Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand).[1][2] The gene is mapped to human chromosome 8q24.[1] The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG.[3] OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. It is secreted both as a monomeric and a dimeric protein.[2][3] Recombinant human OPG is a soluble 20kDa protein containing 174 amino acid residues.
应用
Osteoprotegerin (OPG) human has been used as a supplement in human cell culture during cytokine production.[4]
生化/生理作用
Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage.[2] Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders.[5] It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma.[6]
序列
METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK
外形
Lyophilized from 10 mM Tris pH, 7.5 + 75 mM NaCl.
重悬
Centrifuge the vial prior to opening. Reconstitute in 5 mM Tris, pH 7.5 to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Polymorphisms in three genes are associated with hemorrhagic stroke.
Brain and Behavior, 5, e00395-e00395 (2015)
The tumor necrosis factor superfamily member RANKL suppresses effector cytokine production in group 3 innate lymphoid cells
Bando JK, et al.
Immunity, 48(6), 1208-1219 (2018)
Functions of RANKL/RANK/OPG in bone modeling and remodeling.
Boyce BF and Xing L
Archives of Biochemistry and Biophysics, 473, 139-146 (2008)
Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis.
Goswami S and Sharma-Walia N
BMC Cancer, 15, 935-935 (2015)
H Hsu et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(7), 3540-3545 (1999-03-31)
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. The RANK
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