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Merck
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文件

N5260

Sigma-Aldrich

(-)-尼古丁 酒石酸氢盐

≥98% (TLC), powder

别名:

(-)-1-甲基-2-(3-吡啶基)吡咯烷 (+)-酒石酸氢盐

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About This Item

经验公式（希尔记法）:
C10H14N2 · 2C4H6O6
CAS号:
65-31-6
分子量:
462.41
EC號碼:
200-607-2
分類程式碼代碼:
12352200
PubChem物質ID:
24278591

化驗

≥98% (TLC)

形狀

powder

顏色

white to off-white

溶解度

H2O: 50 mg/mL

SMILES 字串

CN1CCC[C@H]1C2=CC=CN=C2.C

InChI

1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1

InChI 密鑰

RYYKFQGHMYGLEL-PPHPATTJSA-N

基因資訊

human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

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生化／生理作用

原型烟酸乙酰胆碱受体激动剂;天然异构体。

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

289.8 °F

閃點（°C）

143.2 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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(-)-尼古丁 酒石酸氢盐 European Pharmacopoeia (EP) Reference Standard

Y0001023

(-)-尼古丁 酒石酸氢盐

(−)-尼古丁 PESTANAL®, analytical standard

Supelco

36733

(−)-尼古丁

Song Xue et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 22(2), 172-179 (2018-11-20)
Tobacco is highly addictive, and after the development of dependence, it is difficult to quit smoking. Therefore, it is important to understand the factors that play a role in the initiation of smoking. The rewarding effects of nicotine play a
Jhodie R Duncan et al.
Journal of applied physiology (Bethesda, Md. : 1985), 107(5), 1579-1590 (2009-09-05)
During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases the risk of the sudden infant death syndrome (SIDS) two- to fivefold. Serotonergic (5-HT) abnormalities are found, in infants who die of SIDS, in regions of the medulla
Adam J Prus et al.
Pharmacology, biochemistry, and behavior, 91(1), 150-154 (2008-07-23)
The Lewis (LEW) strain of rat appears more sensitive to nicotine than other strains in self-administration, conditioned place preference, and drug discrimination behavioral studies. The present study sought to further evaluate the behavioral effects of chronic nicotine treatment in the
Anthony Renda et al.
BMC neuroscience, 15, 89-89 (2014-07-21)
Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of nicotine self-administration. In this study, we examined whether mice pretreated with chronic nicotine
Jonathan D Raybuck et al.
Behavioral neuroscience, 122(5), 1166-1171 (2008-10-01)
Varenicline, a partial agonist for a4ss2 nicotinic acetylcholine receptors (nAChRs) and full agonist for a7 nAChRs, has been approved for the treatment of smoking cessation. Although recent clinical trials support the efficacy of varenicline for managing global nicotine withdrawal symptoms
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