S0532

番木鳖碱

• 别名: (-)-番木鳖碱
• 经验公式（希尔记法）: C₂₁H₂₂N₂O₂
• CAS号: 57-24-9
• 分子量: 334.41
• Beilstein: 52979
• EC號碼: 200-319-7
• MDL號碼: MFCD00005941
• 分類程式碼代碼: 12352210
• PubChem物質ID: 24899441
• NACRES: NA.54

属性

• mp: 284-286 °C (lit.)
• 溶解度: chloroform: soluble, clear to hazy
• SMILES 字串: [H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]
• InChI: 1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
• InChI 密鑰: QMGVPVSNSZLJIA-FVWCLLPLSA-N

说明

一般說明

Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.

Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.

應用

Strychnine has been used as a glycine receptors antagonist in hippocampal CA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.

Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.

生化／生理作用

At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.

Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the α subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.

惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。

安全信息

• 象形圖: GHS06,GHS09
• 訊號詞: Danger
• 危險聲明: H300 + H310,H410
• 防範說明: P262 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P310
• 危險分類: Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges