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Merck
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文件

N3376

Sigma-Aldrich

烟酰胺

≥98% (HPLC), powder, PARP inhibitor

别名:

吡啶-3-甲酰胺, 烟碱酰胺, 烟酰胺, 维生素 B3, 维生素 PP

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About This Item

经验公式（希尔记法）:
C6H6N2O
CAS号:
98-92-0
分子量:
122.12
Beilstein:
383619
EC號碼:
202-713-4
MDL號碼:
MFCD00006395
分類程式碼代碼:
12352200
PubChem物質ID:
24897638
NACRES:
NA.77

product name

烟酰胺, ≥98% (HPLC), powder

化驗

≥98% (HPLC)

形狀

powder

顏色

white

mp

128-131 °C (lit.)

應用

cell analysis

SMILES 字串

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI 密鑰

DFPAKSUCGFBDDF-UHFFFAOYSA-N

基因資訊

human ... PARP1(142) , SIRT2(22933)

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相关类别

應用

用作某些酶的辅助因子

生化／生理作用

烟酰胺是维生素B3的酰胺衍生物，是PARP抑制剂

特點和優勢

该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

儲存和穩定性

本品可在室温和干燥条件下密封保存。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H319

危險分類

Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

302.0 °F - closed cup

閃點（°C）

150 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
Salvatore Simmini et al.
Nature communications, 5, 5728-5728 (2014-12-17)
The endodermal lining of the adult gastro-intestinal tract harbours stem cells that are responsible for the day-to-day regeneration of the epithelium. Stem cells residing in the pyloric glands of the stomach and in the small intestinal crypts differ in their
Kathrin Schmeisser et al.
Nature chemical biology, 9(11), 693-700 (2013-10-01)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans lifespan. Sirtuins mandatorily convert NAD(+)
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
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