所有图片(1)
About This Item
经验公式（希尔记法）:
C17H17N3 · HCl
CAS号:
分子量:
299.80
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +54 to +62°, c = 0.5 in methanol
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Cl[H].C1C[C@@H](Nc2nc3ccccc3[nH]2)c4ccccc4C1
InChI
1S/C17H17N3.ClH/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17;/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20);1H/t14-;/m1./s1
InChI key
VWEKCDTXUUPBNA-PFEQFJNWSA-N
应用
已使用盐酸 NS8593 研究其对 MDA-MB-231 细胞（M.D. Anderson 和转移性乳腺癌细胞）生长的影响。[1]
生化/生理作用
NS8593 盐酸盐抑制小电导钙激活钾 (SKCa) 通道。
化合物 (R)-N-（苯并咪唑-2-基）-1,2,3,4-四氢-1-萘胺 (NS8593) 可逆性抑制重组 SK3 介导的电流（人和大鼠 SK3），效价约为 100 nM。NS8593 不抑制 125 I-阿帕明结合。NS8593 通过将 Ca 2 + 的激活曲线右移降低钙敏感性，仅轻微影响最大 Ca 2 + 激活的 SK 电流。NS8593 抑制所有 SK1-3 亚型 Ca 2 + 依赖性（K d = 0.42、0.60 和 0.73μM，分别为 0.5μM Ca 2 + 。NS8593 不影响中间电导和大电导的钙激活钾通道（分别为 hIK 和 hBK 通道）。NS8593 介导的抑制作用在高浓度阳性调节剂 NS309 存在时被阻止。
危险声明
危险分类
Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Knockdown of the small conductance Ca2+-activated K+ channels is potently cytotoxic in breast cancer cell lines
Abdulkareem ZA, et al.
British Journal of Pharmacology, 173(1), 177-190 (2016)
Michiko Tashiro et al.
The journal of physiological sciences : JPS, 69(1), 97-102 (2018-06-18)
To examine whether TRPM7, a member of the melastatin family of transient receptor potential channels, is a physiological pathway for Mg2+ entry in mammalian cells, we studied the effect of TRPM7 regulators on cytoplasmic free Mg2+ concentration ([Mg2+]i) of rat
Alayna Mellott et al.
Pflugers Archiv : European journal of physiology, 472(11), 1589-1606 (2020-09-24)
TRPM7 is a cation channel-protein kinase highly expressed in T lymphocytes and other immune cells. It has been proposed to constitute a cellular entry pathway for Mg2+ and divalent metal cations such as Ca2+, Zn2+, Cd2+, Mn2+, and Ni2+. TRPM7
Francesca Luongo et al.
Nutrients, 10(6) (2018-06-19)
Intestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Colon cells express the two highly homologous transient receptor potential melastatin type (TRPM) 6 and 7 Mg2+ channels, but their precise function and the consequences of their mutual interaction are
Goli Ardestani et al.
Cell calcium, 87, 102181-102181 (2020-02-26)
Prior to maturation, mouse oocytes are arrested at the germinal vesicle (GV) stage during which they experience constitutive calcium (Ca2+) influx and spontaneous Ca2+ oscillations. The oscillations cease during maturation but Ca2+ influx continues, as the oocytes' internal stores attain
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