N156

Naltriben methanesulfonate hydrate

≥98% (HPLC), solid

• 别名: NTB hydrate
• 经验公式（希尔记法）: C₂₆H₂₅NO₄ · CH₄O₃S · xH₂O
• CAS号: 1309441-44-8
• 分子量: 511.59 (anhydrous basis)
• MDL號碼: MFCD11046015
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278045
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 藥物控制: regulated under CDSA - not available from Sigma-Aldrich Canada
• 顏色: off-white
• 溶解度: DMSO: 14 mg/mL at ~60 °C
• 儲存溫度: −20°C
• SMILES 字串: O.CS(O)(=O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6oc7ccccc7c6C[C@@]35O)CC8CC8
• InChI: 1S/C26H25NO4.CH4O3S.H2O/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14;1-5(2,3)4;/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2;1H3,(H,2,3,4);1H2/t20-,24+,25+,26-;;/m1../s1
• InChI 密鑰: VAGWKZSGWSRENH-HIAJFTJMSA-N

说明

應用

Naltriben methanesulfonate hydrate has been used in the assessment of parasite growth and evaluation of growth inhibition. It has also been used to understand the action of deltorphin-II in exhibiting its antimalarial effect.

生化／生理作用

Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkephalin > deltorphin II = DPDPE = etorphine > levallorphan = diprenorphine = nalorphine = naltrindole.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)