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品質等級
化驗
≥97% (HPLC)
形狀
solid
顏色
yellow
溶解度
DMSO: 15 mg/mL
SMILES 字串
Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O
InChI
1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChI 密鑰
RCEFMOGVOYEGJN-UHFFFAOYSA-N
一般說明
Icilin是一种合成的冷却剂,调节人瞬时受体电位阳离子通道(TRPA1)。Icilin抑制瞬时受体电位阳离子通道亚家族M成员8(TRPM8)并调节钙释放。Icilin还抑制瞬时受体电位香草酸亚型3(TRPV3)。
應用
Icilin已被用作前腹膜内侧前视区(VMPO)神经元的冷却剂。
生化/生理作用
豌豆球蛋白是CMR1冷和薄荷醇敏感受体的有效激动剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3
TheScientificWorldJournal, 2012(6), 859-869 (2012)
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The Journal of Biological Chemistry, 284(7), 4102-4111 (2009)
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