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M8046

Sigma-Aldrich

米非司酮

≥98%

别名:

11β-（4-二甲基-氨基）-苯基17β-羟基-17-（1-丙炔基）-雌甾-4,9-三胺-3-酮, RU-38486, RU-486

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100 MG
$252.00
500 MG
$890.00
1 G
$1,550.00

$252.00

预计发货时间2025年4月07日详情

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100 MG
$252.00
500 MG
$890.00
1 G
$1,550.00

About This Item

经验公式（希尔记法）:
C29H35NO2
CAS号:
84371-65-3
分子量:
429.59
MDL编号:
MFCD00867226
UNSPSC代码:
51111800
PubChem化学物质编号:
24278572
NACRES:
NA.77

$252.00

预计发货时间2025年4月07日详情

获取大包装报价

生物来源

synthetic (organic)

无菌性

non-sterile

方案

≥98%

表单

powder

技术

inhibition assay: suitable

溶解性

ethanol: 50 mg/mL, clear, greenish-yellow

创始人

Danco Laboratories

运输

ambient

储存温度

2-8°C

SMILES字符串

[H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C

InChI

1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChI key

VKHAHZOOUSRJNA-GCNJZUOMSA-N

基因信息

human ... AR(367) , ESR1(2099) , ESR2(2100) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , NR3C1(2908) , NR3C2(4306) , PGR(5241)
mouse ... Nr3c1(14815)
rat ... Nr3c1(24413) , Tat(24813)

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一般描述

米非司酮是一种合成类固醇，可用于治疗库欣综合征和子宫平滑肌瘤。低剂量使用时，它通过结合细胞内孕酮受体选择性地拮抗孕酮。高剂量使用时，米非司酮可阻断糖皮质激素受体上的皮质醇，影响下丘脑-垂体-肾上腺轴，导致循环皮质醇增加，从而控制某些患者的高血糖。此外，米非司酮对糖皮质激素II受体的亲和力高于对糖皮质激素I受体的。在终止妊娠的情况下，米非司酮会破坏孕酮。[1]

应用

米非司酮用于：
  • 诱导破坏增殖和分泌期的子宫内膜基质细胞[2]
  • 建立小鼠早产(PTB)模型，研究非早产和PTB宫颈成熟机制的差异[3]
  • 激活果蝇基因开关gal4[4]
  • 研究性类固醇对于前列腺素分泌的影响[5]

生化/生理作用

因此，米非司酮被认为是一种强力的堕胎药。它还能抑制人绒毛膜促性腺激素。[6]米非司酮导致蜕膜坏死。[7]
米非司酮(RU-486)具有孕激素受体拮抗剂和糖皮质激素受体拮抗剂活性。

特点和优势

该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物是由Danco实验室研发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

预防措施声明

P201 - P308 + P313

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF3658V
WXBF0030V
WXBD7927V
WXBD5791V
WXBD2264V

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Mifepristone
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Questions

1–9 of 9 Questions  

  1. What are the recommended storage conditions for stock solutions of item A8727, Antalarmin hydrochloride?

    1 answer

    1. Store stock solutions of item A8727, Antalarmin hydrochloride below -20°C and ensure a tight seal before storage.

      Helpful?

  2. What is the recommended method for storing stock solutions of item P0884, (±)-Propranolol hydrochloride?

    1 answer

    1. For P0884, stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. Typically, the stock solution can be kept for several months.

      Helpful?

  3. How should stock solutions for item I6138, Idazoxan hydrochloride, be stored?

    1 answer

    1. Stock solutions for item I6138, Idazoxan hydrochloride, are stable for up to 3 months at -20°C.

      Helpful?

  4. What are the recommended storage conditions for stock solutions of Mifepristone (item M8046)?

    1 answer

    1. The stock solutions of Mifepristone (item M8046) can be stored at -20°C and remain stable for up to 3 months.

      Helpful?

  5. How many pills is in the container of mifepristone ( 100mg)

    1 answer

    1. This item is supplied in a powder form, not in a pill form. Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals.

      Helpful?

  6. Can solutions of Mifepristone, Product M8046, be stored?

    1 answer

    1. Stock solutions of 1 mM mifepristone in ethanol can be stored at -20 °C. The top of the container should be sealed with Parafilm to prevent solvent evaporation. Solutions in ethanol, properly stored and handled, are probably good for several months (based on the structure of the compound), but we have no specific information on this.

      Helpful?

  7. What is Mifepristone, Product M8046, soluble in?

    1 answer

    1. Mifepristone is soluble in ethanol at 50 mg/mL; heat may be required to dissolve the compound at this concentration.  It is also soluble in DMSO at 20 mg/mL.

      Helpful?

  8. Where can I find information on usage of Mifepristone, Product M8046?

    1 answer

    1. The Sigma-Aldrich website listing has several cited articles with hyperlinks to the abstracts. These references can be found under the reference tab on the M8046 product webpage.

      Helpful?

  9. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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