M3935

Meloxicam sodium salt hydrate

≥98% (HPLC)

• 别名: 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate, Metacam sodium salt hydrate, Mobec sodium salt hydrate, UH-AC 62XX sodium salt hydrate
• 经验公式（希尔记法）: C₁₄H₁₂N₃NaO₄S₂ · xH₂O
• CAS号: 71125-39-8
• 分子量: 373.38 (anhydrous basis)
• MDL號碼: MFCD11046047
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278802
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: light yellow to dark yellow
• 溶解度: DMSO: 5 mg/mL, clear
• 起源: Boehringer Ingelheim
• 儲存溫度: room temp
• SMILES 字串: O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O
• InChI: 1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1
• InChI 密鑰: IZBZAOZGNNQKPJ-UHFFFAOYSA-M
• 基因資訊: human ... PTGS2(5743)

说明

應用

Meloxicam sodium salt hydrate has been used:

• as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor[1]
• as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures[2]
• as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)[3]
• to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells[4]

生化／生理作用

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution.[5] Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain.[6] Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats.[7] Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro.[8] It promotes apoptosis in hepatocellular carcinoma.[1]

特點和優勢

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H319,H335
• 防範說明: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable