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L5293

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0111:B4

Ready Made solution, 1 mg/mL

别名:

LPS

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2 ML
$438.00

$438.00

国内现货，预计发货时间2025年4月07日详情

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2 ML
$438.00

About This Item

CAS号:
93572-42-0
MDL编号:
MFCD00164401
UNSPSC代码:
12352201
NACRES:
NA.25

$438.00

国内现货，预计发货时间2025年4月07日详情

获取大包装报价

生物来源

Escherichia coli (O111:B4)

质量水平

200

表单

aqueous solution

浓度

1 mg/mL

颜色

colorless to faint yellow

溶解性

water: soluble

运输

wet ice

储存温度

2-8°C

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应用

大肠肝菌O111:B4来源脂多糖可用于：
  • 刺激体内猪的肝脏组织[1]和体外仔猪回肠组织的炎症反应[2]
  • 刺激体外自然杀手(NK)细胞[3]和肝B细胞[4]
  • 在标准兔模型中诱发关节炎[5]

脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。

生化/生理作用

脂多糖(LPS)分布在细胞膜的外层，并且存在于无包膜菌株的细胞表面。LPS可维持外膜的完整性。此外，还可保护细胞免受胆盐应激和亲脂抗生素的影响。[6]

制备说明

产物可溶于水（5mg/ml）或细胞培养基（1mg/ml），产生浑浊的、淡黄色溶液。在经过涡旋和加温至 70-80oC 后，在水溶的盐水中得到更浓缩、但仍然浑浊的溶液（20mg/ml）。脂多糖是在各种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。有机溶剂不能提供更澄清的溶液。甲醇产生具有漂浮物的混浊悬浮液，而水产生均匀混浊的溶液。

其他说明

为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。

相关产品

产品编号
说明
价格

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000408042
0000408042
0000294757
0000212837
0000219279

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Effects of dietary beta-glucans supplementation on cytokine expression in porcine liver
Ryan M, et al.
Journal of Animal Science, 90(suppl-4), 40-42 (2012)
Ryan J Lu et al.
Nature aging, 1(8), 715-733 (2021-09-14)
Neutrophils are the most abundant human white blood cell and constitute a first line of defense in the innate immune response. Neutrophils are short-lived cells, and thus the impact of organismal aging on neutrophil biology, especially as a function of
NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection
Wesselkamper S, et al.
Journal of immunology (Baltimore, Md. : 1950), 181(8), 5481-5489 (2008)
Effect of maternal seaweed extract supplementation on suckling piglet growth, humoral immunity, selected microflora, and immune response after an ex vivo lipopolysaccharide challenge
Leonard SG, et al.
Journal of Animal Science, 90(2), 505-514 (2012)
Imaging of normal and pathologic joint synovium using nonlinear optical microscopy as a potential diagnostic tool
Tiwari N, et al.
Journal of Leukocyte Biology, 15(5), 056001-056001 (2010)
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商品

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

相关内容

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is recommended for the storage of longer duration once opened? Is it better to keep at 2°C-8°C for 1-2 years or to freeze it (-80°C or -20°C) and thaw it gently when needed?

    1 answer

    1. This product is stable at 2-8°C at least until the assigned retest date, provided that no contaminants have been introduced. The recommended retest date is lot specific and reported in the product Certificate of Analysis. The stability of the product in dilute form or beyond the assigned retest date has not been determined. However, LPS products prepared from the powder form may be stored in 1 mg/mL aliquots for up to 2 years at -20°C. The storage of solutions at -80°C has not been determined. Please see the link below to review additional information regarding the stability and preparation of Lipopolysaccharides:
      https://www.sigmaaldrich.com/technical-documents/protocol/clinical-testing-and-diagnostics-manufacturing/bacteriology/lipopolysaccharides

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  4. What solvent is the product L5293-2ML dissolved in?

    1 answer

    1. The solvent information for this product is proprietary, but it is acknowledged to contain water, while the remaining components remain undisclosed.

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  5. Bonjour, Comment ce LPS a t'il été extrait / Purifié ?

    1 answer

    1. This product is a sterile filtered solution. The extraction method for this material is considered proprietary, however it is chromatographically purified.

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