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Merck
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主要文件

L4040

Sigma-Aldrich

乳铁蛋白 人

recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)

别名:

Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin

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100 MG
$268.00

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100 MG
$268.00

About This Item

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

$268.00


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生物来源

human

重组

expressed in rice

方案

≥70% protein basis (Bradford)
≥90% (SDS-PAGE)

表单

powder

技术

microbiological culture: suitable

溶解性

H2O: soluble 10 mg/mL

UniProt登记号

储存温度

2-8°C

基因信息

human ... LTF(4057)

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应用

使用乳铁蛋白在铁限制培养基中培养变形链球菌[1] 用于测试乳铁蛋白在体外是否阻碍上皮细胞黏附 [2] 同时用于测试血液细胞因子浓度对急性肺炎的诊断价值。[3]

生化/生理作用

乳铁蛋白是一种铁结合蛋白。在结构上与血浆铁转运蛋白转铁蛋白相似;但是乳铁蛋白对铁的亲和力要高得多(250 倍)。在初乳中含量非常丰富,少量也可见于泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中。由粘膜上皮和中性粒细胞组成,在炎症刺激下由这些细胞释放。细菌的生长被其隔离铁的能力所抑制,也通过其 N 端与脂多糖结合使细菌细胞壁通透性增加。乳铁蛋白可以通过与病毒包膜蛋白紧密结合来抑制病毒感染。这通过阻断结合域阻止了细胞与病毒的融合。乳铁蛋白似乎部分通过刺激中性粒细胞激活剂白细胞介素-8 的释放来激活宿主防御系统。还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Thuy Nguyen Thi Dao et al.
Journal of extracellular vesicles, 11(2), e12195-e12195 (2022-02-22)
Cancer cell-derived extracellular vesicles (EVs) are promising biomarkers for cancer diagnosis and prognosis. However, the lack of rapid and sensitive isolation techniques to obtain EVs from clinical samples at a sufficiently high yield limits their practicability. Chimeric nanocomposites of lactoferrin
Chuang Guo et al.
Food & function, 11(8), 7183-7196 (2020-08-07)
Lactoferrin (Lf), an iron-binding glycoprotein, has been shown to possess antioxidant and anti-inflammatory properties and exert modulatory effects on lipid homeostasis and non-alcoholic fatty liver disease (NAFLD), but our understanding of its regulatory mechanisms is limited and inconsistent. We used
Qingsheng Kong et al.
Molecular and cellular biochemistry, 406(1-2), 293-299 (2015-05-20)
The metalloprotease lethal factor (LF) from Bacillus anthracis plays a vital role in anthrax toxin action, and thus becomes a target for anti-anthrax therapy. Following the guidelines based on existing metalloprotease inhibitors, we designed a 'first-generation' LF inhibitor R9LF-1. This
Shelton W Wright et al.
PLoS neglected tropical diseases, 14(8), e0008495-e0008495 (2020-08-09)
Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not require BSL-3 conditions for study. Lactoferrin is an iron-binding glycoprotein that can
P Kragsbjerg et al.
Thorax, 50(12), 1253-1257 (1995-12-01)
The role of cytokines in the pathogenesis of pneumonia is still poorly understood. In a previous study the diagnostic value of measuring blood concentrations of interleukin 6 and interferon gamma was established. In the present study the value of blood

Questions

  1. Could you please specify the % of iron saturation in this product?

    1 answer
    1. The iron content of this material is 0.12%. This information is reported in the lot specific Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
      https://www.sigmaaldrich.com/US/en/product/sigma/l4040#product-documentation

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