H3160

氢化可的松

meets USP testing specifications

• 别名: 11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M
• 经验公式（希尔记法）: C₂₁H₃₀O₅
• CAS号: 50-23-7
• 分子量: 362.46
• Beilstein: 1354819
• EC 号: 200-020-1
• MDL编号: MFCD00011654
• UNSPSC代码: 51111800
• PubChem化学物质编号: 24895560
• NACRES: NA.21

属性

• 生物来源: plant (wild yam)
• Agency: USP/NF; meets USP testing specifications
• 方案: 97.0-102.0% dry basis
• 表单: powder
• 效能: 0.004-0.005 μg/mL
• mp: 211-214 °C (lit.)
• 溶解性: water: soluble 0.28 g/L at 25 °C
• 应用: pharmaceutical (small molecule)
• SMILES字符串: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• 基因信息: human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) ; rat ... Ar(24208) , Nr3c1(24413)

说明

应用

• Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024).


• Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024).

生化/生理作用

肾上腺皮质分泌的原始糖皮质激素。

肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍，但 Na²⁺ 保留效力要低得多。

外形

室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H360Df,H373
• 预防措施声明: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危险分类: Repr. 1A - STOT RE 2
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Gloves