GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:
to study the anticancer effects of statins along with GGTI 298[1]
to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium[2]
to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population[3]
生化/生理作用
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
特点和优势
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International journal of molecular sciences, 21(17) (2020-09-06)
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