Various solvents, including ethanol, are reported to inhibit forskolin-mediated activation of adenylate cyclase. Dimethyl sulfoxide (DMSO) is the recommended solvent; at a final concentration of 5% or less, little if any inhibition of adenylate cyclase activation will occur. A 50 mM stock solution of forskolin can be prepared by solubilizing 10 mg of forskolin in 488 µL of fresh, high purity, and anhydrous DMSO. After reconstitution, aliquot and freeze at -20°C. The 50 mM stock solution can be diluted 1:100 in DMSO to achieve a 500 µM working stock solution.
F3917
毛喉素
For use in molecular biology applications
别名:
7β-乙酰氧基-1α,6β,9α-二羟基-8,13-环氧-半日花-14-EN-11-酮, 洋紫苏醇, 考福新
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10 MG
$451.00
25 MG
$680.40
$451.00
预计发货时间2025年1月31日详情
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10 MG
$451.00
25 MG
$680.40
About This Item
经验公式（希尔记法）:
C22H34O7
CAS号:
分子量:
410.50
Beilstein:
1692716
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.52
$451.00
预计发货时间2025年1月31日详情
推荐产品
生物源
Coleus forskohlii
品質等級
描述
for activation of T cells
產品線
BioReagent
化驗
≥98% (HPLC)
形狀
powder
分子量
410.50 g/mol
顏色
white to off-white
溶解度
ethanol: soluble
適合性
suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells
儲存溫度
room temp
SMILES 字串
CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C
InChI
1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChI 密鑰
OHCQJHSOBUTRHG-KGGHGJDLSA-N
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一般說明
毛喉素是从Coleus forskohlii分离提取的细胞渗透双萜。
生化／生理作用
具有抗高血压、正性变力作用和腺苷酸环化酶活化特性的细胞通透性二萜类化合物。它的许多生物学作用是由于其对腺苷酸环化酶的激活以及由此而导致的细胞内cAMP浓度增加。毛喉素可影响钙电流并抑制MAP激酶。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Dermal
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
A Ramón-Cueto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(10), 3803-3815 (1998-06-06)
The lack of axonal regeneration in the injured adult mammalian spinal cord leads to permanent functional impairment. To induce axonal regeneration in the transected adult rat spinal cord, we have used the axonal growth-promoting properties of adult olfactory bulb ensheathing
Jin Wei Chung et al.
Biology of reproduction, 86(3), 80-80 (2011-12-03)
The signaling molecule DHH, secreted by Sertoli cells, has essential regulatory functions in testicular differentiation. DHH is required for the differentiation of peritubular myoid cells that line the seminiferous cords and steroidogenic Leydig cells. The testicular cords in Dhh-null male
T Marchetti et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 910-920 (2014-03-25)
Obstetric antiphospholipid syndrome (APS) is defined by pregnancy complications associated with antiphospholipid antibodies (aPL). The mechanisms of the pathogenic effects of aPL in pregnancy are poorly understood. Toll-like receptors (TLR) have been implicated previously in APS. The aims of our
Koji Yokoyama et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 302-314 (2014-10-11)
Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore
Jeanne Ster et al.
The Journal of physiology, 587(1), 101-113 (2008-11-13)
Extensive work has shown that activation of the cAMP-dependent protein kinase A (PKA) is crucial for long-term depression (LTD) of synaptic transmission in the hippocampus, a phenomenon that is thought to be involved in memory formation. Here we studied the
实验方案
Learn how to cultivate similar-sized iPSC-derived colon organoids using Millicell® Microwell plates and perform a forskolin-induced swelling assay.
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How can i prepare 500uM Forskolin (10mg) and where can the prepared solution be stored?
1 answer-
Helpful?
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What is the shelf life of the solid form of forskolin?
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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How should I store a DMSO or ethanol solution of Product F3917, Forskolin?
1 answer-
Forskolin solutions at 5 mg/mL in either ethanol or DMSO have been found to be stable for at least 6 months at room temperature, as determined by HPLC analysis.
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How can I make an aqueous solution of Product F3917, Forskolin?
1 answer-
Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and performing subsequent dilutions in water. Similar results were obtained with DMSO.
Helpful?
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Will residual solvents inhibit forskolin activation of adenylate cyclase?
1 answer-
Various solvents, including ethanol, inhibit the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions, because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.
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