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方案
≥99%
溶解性
DMSO: 38 mg/mL
储存温度
−20°C
SMILES字符串
Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
InChI
1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChI key
INVTYAOGFAGBOE-UHFFFAOYSA-N
基因信息
human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)
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一般描述
优先于HDAC3（IC50=8 μM）抑制HDAC1（IC50 = 300nM）。 对HDAC8（IC50>100 μM）无抑制活性。
应用
MS-275已被用作组蛋白脱乙酰酶-1抑制剂。[1]
生化/生理作用
HDAC抑制剂，抗增殖。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Repr. 1A
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
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