E0407

Estramustine sodium phosphate

• 别名: Estra-1,3,5(10)triene-3,17ß-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt, Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt
• 经验公式（希尔记法）: C₂₃H₃₀Cl₂NNa₂O₆P
• CAS号: 52205-73-9
• 分子量: 564.35
• EC號碼: 257-735-7
• MDL號碼: MFCD00866320
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329798968
• NACRES: NA.28

属性

• 化驗: ≥85.0% (HPLC)
• 形狀: powder
• 溶解度: H₂O: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: [H][C@]12[C@@]([C@@](CC[C@@H]3OP([O-])([O-])=O)([H])[C@]3(C)CC2)([H])CCC4=C1C=CC(OC(N(CCCl)CCCl)=O)=C4.[Na+].[Na+]
• InChI: 1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1
• InChI 密鑰: IIUMCNJTGSMNRO-VVSKJQCTSA-L
• 基因資訊: human ... ESR2(2100)

说明

生化／生理作用

Estradiol mustard prodrug, which binds estradiol receptors irreversibly. Highly effective in treatment of advanced metastatic prostate cancer. Depolymerizes microtubules by binding to microtubule associated proteins (MAPs).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves