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Merck
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文件

D7145

Sigma-Aldrich

2'-脱氧鸟苷 一水合物

99-100%

别名:

9-（2-脱氧-β-D-呋喃核糖基）鸟嘌呤, 鸟嘌呤-2′-脱氧核苷

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About This Item

经验公式（希尔记法）:
C10H13N5O4 · H2O
CAS号:
312693-72-4
分子量:
285.26
Beilstein:
39814
MDL號碼:
MFCD00150760
分類程式碼代碼:
41106305
PubChem物質ID:
24894083
NACRES:
NA.51

生物源

synthetic (organic)

品質等級

200

化驗

99-100%

形狀

powder

溶解度

1 M NH4OH: 50 mg/mL, clear, colorless

SMILES 字串

O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1

InChI

1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1

InChI 密鑰

LZSCQUCOIRGCEJ-FPKZOZHISA-N

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應用

2′-脱氧鸟苷一水合物作为核苷补充剂，可用于：
  • 研究其对脱氧尿苷激酶(dguok)突变斑马鱼中线粒体DNA拷贝数的影响，
  • 在组织培养基中用于合成脱氧核糖核苷酸(dNTP)，
  • 在RPMI(Roswell Park Memorial Institute)-1640培养基中用于去除内源性胸腺细胞

生化／生理作用

脱氧鸟苷(dG)是一种嘌呤核苷，在激酶的连续磷酸化作用下可形成脱氧鸟苷三磷酸(dGTP)，dGTP可用于通过DNA聚合酶和逆转录酶合成DNA。在四种经典碱基中，脱氧鸟苷是最富电子的碱基，含有多个易受氧化损伤的亲核位点，因此脱氧鸟苷及其氧化衍生物可用于研究核苷和核苷酸的氧化损伤机制。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Zimu Deng et al.
Methods in molecular biology (Clifton, N.J.), 1323, 151-158 (2015-08-22)
Reconstituted thymus organ culture is based on fetal thymus organ culture (FTOC). Purified thymocyte populations, from genetically modified mice or even from other species, are cultured in vitro with thymic lobes depleted of their endogenous thymocytes (by 2'-deoxyguanosine treatment) to
Takeji Takamura-Enya et al.
Bioorganic & medicinal chemistry letters, 21(14), 4206-4209 (2011-06-21)
BODIPY-modified 2'-deoxyguanosine was synthesized for use as a detection reagent for genotoxic compounds. BODIPY-FL is a well known fluorescence reagent whose fluorescent light emission diminishes near a guanine base by a photo-induced electron transfer process. We attached BODIPY-Fl to the
Kasper Broedbaek et al.
Free radical biology & medicine, 51(8), 1473-1479 (2011-08-09)
The increasing prevalence of diabetes together with the associated morbidity and mortality calls for additional preventive and therapeutic strategies. New biomarkers that can be used in therapy control and risk stratification as alternatives to current methods are needed and can
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Free radical research, 39(10), 1071-1081 (2005-11-22)
An association between exposure to ambient particulate matter (PM) and increased incidence of mortality and morbidity due to lung cancer and cardiovascular diseases has been demonstrated by recent epidemiological studies. Reactive oxygen species (ROS), especially hydroxyl radicals, generated by PM
Aaron M Fleming et al.
Organic & biomolecular chemistry, 15(39), 8341-8353 (2017-09-25)
In DNA, 2'-deoxyguanosine (dG) is susceptible to oxidative modification by reactive oxygen species (ROS) yielding many products, one of which is 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG). Interestingly, dOG is stable but much more labile toward oxidation than dG, furnishing 5-guanidinohydantoin-2'-deoxyribose (dGh) that is
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