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Merck

P0256

Sigma-Aldrich

吡啶硫胺 氢溴酸盐

~95%, crystalline

别名:

1-([4-氨基-2-甲基]-5-嘧啶基甲基)-2-甲基-3-(β-羟乙基)溴化吡啶鎓, 新吡啶硫胺

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1 MG
$217.00
5 MG
$568.00
10 MG
$978.00

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1 MG
$217.00
5 MG
$568.00
10 MG
$978.00

About This Item

经验公式(希尔记法):
C14H18N4O · 2HBr
CAS号:
分子量:
420.14
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

$217.00


请联系客服了解存货情况

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方案

~95%

表单

crystalline

颜色

off-white to yellow

储存温度

2-8°C

SMILES字符串

Br.[Br-].Cc1ncc(C[n+]2cccc(CCO)c2C)c(N)n1

InChI

1S/C14H19N4O.2BrH/c1-10-12(5-7-19)4-3-6-18(10)9-13-8-16-11(2)17-14(13)15;;/h3-4,6,8,19H,5,7,9H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1

InChI key

DMVBWVASDWGFNH-UHFFFAOYSA-M

一般描述

吡啶硫胺氢溴酸盐是一种杂环化合物合成砌块,由于能够模拟硫胺素缺乏症且可能用于开发具有实用药理特性的新化合物,因而成为重要的有机合成和药物化学工具。 [1] [2]

应用

吡啶硫胺氢溴酸盐可用作合成焦磷酸吡硫胺的前体。 [2]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Xiaohua He et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32(10), 2207-2216 (2007-02-15)
The relative roles of alcohol and thiamine deficiency in causing brain damage remain controversial in alcoholics without the Wernicke-Korsakoff syndrome. Experimental control over alcohol consumption and diet are impossible in humans but can be accomplished in animal models. This experiment
Stéphane Thore et al.
Science (New York, N.Y.), 312(5777), 1208-1211 (2006-05-06)
Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal
Steven Anzalone et al.
The European journal of neuroscience, 32(5), 847-858 (2010-08-24)
Although the key neuropathology associated with diencephalic amnesia is lesions to the thalamus and/or mammillary bodies, functional deactivation of the hippocampus and associated cortical regions also appear to contribute to the memory dysfunction. For example, there is loss of forebrain
Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine
Sudarsan, et al.
Chemistry & Biology, 12, 1325-1335 (2005)
Jessica J Roland et al.
Neurobiology of learning and memory, 87(1), 123-132 (2006-09-19)
A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate the dynamic role of hippocampal and striatal acetylcholine (ACh) efflux across acquisition of a nonmatching-to-position (NMTP) T-maze task. Changes in ACh efflux were measured in rats

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