The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
推荐产品
产品名称
Dynasore 水合物,
形狀
powder
品質等級
儲存條件
protect from light
顏色
off-white
溶解度
DMSO: ≥10 mg/mL
H2O: insoluble
儲存溫度
−20°C
SMILES 字串
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
InChI 密鑰
FKWZHQSDBMSHTN-ZIOFAICLSA-N
一般說明
應用
生化／生理作用
Dynasore是一种细胞渗透性、可逆的非竞争性发动蛋白1和发动蛋白2的GTP酶活性抑制剂。
特點和優勢
该化合物是环核苷酸研究的推荐产品。点击此处，了解更多精选环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Florian Ehlgen et al.
PloS one, 7(6), e38781-e38781 (2012-06-22)
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane
Dynasore-not just a dynamin inhibitor
Preta G, et al.
Cell communication and signaling : CCS, 13(1), 24-24 (2015)
G J Hofmeyr et al.
BJOG : an international journal of obstetrics and gynaecology, 121(8), 951-957 (2014-03-14)
Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in
Dynasore disrupts trafficking of HSV proteins
Mues MB, et al.
Journal of Virology, JVI-00636 (2015)
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies
Fischer E, et al
Clinical Cancer Research, clincanres-clinca0644 (2012)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
1 answer-
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How can I store a solution of Product D7693, Dynasore hydrate?
1 answer-
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can I use to make a solution of Product D7693, Dynasore hydrate?
1 answer-
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
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