The history of drug treatments, and particularly the discovery of certain molecules, led toan evolution in psychiatric practices. The discovery of the therapeutic properties of chlorpromazine in 1952 by Jean Delay and Pierre Deniker revolutionised the relational process between patients
Systemic uptake of chlorpromazine after delivery via retrobulbar injection.
Ruben Kuruvilla et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 130(10), 1348-1349 (2012-10-10)
Journal of molecular recognition : JMR, 26(4), 165-174 (2013-03-05)
Protein-protein interactions play central roles in physiological and pathological processes. The bases of the mechanisms of drug action are relevant to the discovery of new therapeutic targets. This work focuses on understanding the interactions in protein-protein-ligands complexes, using proteins calmodulin
Antipsychotic therapy over half a century: a tale of discovery from chlorpromazine to aripiprazole.
Sridhar Natesan et al.
The National medical journal of India, 25(4), 193-195 (2013-01-03)
Phenothiazines when exposed to white light or to UV radiation undergo a variety of reactions that result in degradation of parental compound and formation of new species. This process is slow and may be sped up with exposure to high