A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

• 别名: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
• 经验公式（希尔记法）: C₆H₈ClN₇O · HCl · xH₂O
• CAS号: 2016-88-8
• 分子量: 266.09 (anhydrous basis)
• MDL编号: MFCD03703482
• UNSPSC代码: 12352200
• PubChem化学物质编号: 24277817
• NACRES: NA.77

属性

• 产品名称: Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
• 质量水平: 200
• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: yellow
• mp: 285-288 °C (dec.)
• 溶解性: H₂O: 50 mg/mL, clear, yellow-green
• 创始人: Perrigo
• 储存温度: room temp
• SMILES字符串: O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
• InChI: 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
• InChI key: WDZJJRLYFQNCQL-UHFFFAOYSA-N
• 基因信息: human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124) ; mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544) ; rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

说明

应用

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

生化/生理作用

Selective T-type Ca²⁺ and epithelial sodium channel blocker

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Protect from light.

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H301
• 预防措施声明: P264 - P270 - P301 + P310 - P405 - P501
• 危险分类: Acute Tox. 3 Oral
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges