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D3876

Sigma-Aldrich

2'-脱氧尿苷 5'-单磷酸 二钠盐

Sigma Grade

别名:

dUMP

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100 MG
$189.60
250 MG
$604.00
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$1,850.00

$189.60

目录价$316.00节省 40%

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100 MG
$189.60
250 MG
$604.00
1 G
$1,850.00

About This Item

线性分子式:
C9H11N2O8PNa2
CAS号:
42155-08-8
分子量:
352.15
EC號碼:
255-687-1
MDL號碼:
MFCD00065282
分類程式碼代碼:
41106305
PubChem物質ID:
24893787
NACRES:
NA.51

$189.60

目录价$316.00节省 40%

有货详情

生物源

synthetic (organic)

品質等級

200

等級

Sigma Grade

化驗

≥98% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O

InChI

1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;

InChI 密鑰

WXIVKKBDJOCRNB-UHFFFAOYSA-N

相关类别

一般說明

2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）是胸苷酸合酶的底物，并转化为脱氧胸苷单磷酸（dTMP）。[1]

應用

2′-脱氧尿苷-5′-单磷酸二钠盐已用于：
  • 超高效液相色谱-串联质谱（UPLC/MS/MS）法测定[1]
  • 刺激暴露于流行性感冒病毒抗原人外周血单个核细胞（PBMC）的增殖[2]
  • 胸苷酸合成酶活性测定幽门螺杆菌[3]

苷酸合成酶（TS）（EC 2.1.1.45）使用2′-脱氧尿苷5′-单磷酸（dUMP）从头生产dTMP。在潜在的化疗应用中研究dUMP类似物时，将dUMP用作参考底物。

生化／生理作用

甲氨蝶呤可抑制2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）转化为嘧啶。[1]在甲基化步骤中将dUMP抑制为脱氧胸苷单磷酸（dTMP）是控制细菌和真核细胞生长的关键。[3]

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000411514
0000411514
0000374876
0000374873
0000355535

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Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 21(10), 1003-1009 (2005)
Zachary Newby et al.
Biochemistry, 45(24), 7415-7428 (2006-06-14)
The enzyme thymidylate synthase (TS) catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to 2'-deoxythymidine 5'-monophosphate. Using kinetic and X-ray crystallography experiments, we have examined the role of the highly conserved Tyr-261 in the catalytic mechanism of TS. While Tyr-261
Glyn R Hemsworth et al.
The Journal of biological chemistry, 286(18), 16470-16481 (2011-04-02)
Members of the Leishmania genus are the causative agents of the life-threatening disease leishmaniasis. New drugs are being sought due to increasing resistance and adverse side effects with current treatments. The knowledge that dUTPase is an essential enzyme and that
Dimitri Topalis et al.
The FEBS journal, 272(24), 6254-6265 (2005-12-13)
Anti-poxvirus therapies are currently limited to cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], but drug-resistant strains have already been characterized. In the aim of finding a new target, the thymidylate (TMP) kinase from vaccinia virus, the prototype of Orthopoxvirus, has been overexpressed in Escherichia coli
Peter S Ludwig et al.
European journal of medicinal chemistry, 40(5), 494-504 (2005-05-17)
Amphiphilic anticancer prodrugs of 5'-fluoro-2'-deoxyuridine-5'-monophosphate (5-FdUMP) were synthesized according to the hydrogen phosphonate method by coupling lipophilic cytosine derivatives or a phospholipid with 5-fluoro-2'-deoxyuridine (5-FdU). Studies within the in vitro Anticancer Screen Program of the National Cancer Institute have demonstrated
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