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Merck

D7625

Sigma-Aldrich

2′-脱氧胞苷 5′-单磷酸 钠盐

Sigma Grade, ≥98%

别名:

dCMP, 胞嘧啶脱氧核苷酸

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About This Item

线性分子式:
C9H12N3O7PNa2
CAS号:
分子量:
351.16
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

microbial (fermentation)

等級

Sigma Grade

化驗

≥98%

形狀

powder

儲存溫度

−20°C

SMILES 字串

[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(O)=O)O2

InChI

1S/C9H14N3O7P.Na.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17);;

InChI 密鑰

BLEUYVBRJBDVEH-UHFFFAOYSA-N

相关类别

應用

2′-脱氧胞苷-5′-单磷酸钠盐已被用于:
  • 肾细胞癌(RCC)细胞SN12C的核苷稳定性研究
  • 人肠道Caco-2细胞系和外周血单核细胞(PBMC)的细胞增殖研究
  • 作为dsDNA激活诱导的胞苷脱氨酶结晶中的配体
将2′-脱氧胞苷-5-单磷酸(CMP)用作尿苷一磷酸(UMP)/胞苷一磷酸(CMP)激酶(EC 2.7.4.4)的底物以形成 dCDP,其在磷酸化至 dCTP 后,支持 DNA 和 RNA 生物合成。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Zauri M, et al.
Nature, 524(7563), 114-114 (2015)
Rafael Andrade Caceres et al.
Journal of molecular modeling, 14(5), 427-434 (2008-03-18)
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to, respectively, UDP and
AID recognizes structured DNA for class switch recombination
Qiao Q, et al.
Molecular Cell, 67(3), 361-373 (2017)
Chih-Hung Hsu et al.
Molecular pharmacology, 67(3), 806-814 (2004-11-20)
Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs.
Dietary nucleotides and intestinal cell lines: I. Modulation of growth
Holen E and Jonsson R
Nutrition Research (New York, N.Y.), 24(3), 197-207 (2004)

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