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D054

Sigma-Aldrich

R（+）-SCH-23390 盐酸盐

≥98% (HPLC), solid

别名:

R（+）-7-氯-8-羟基-3-甲基-1-苯基-2，3，4，5-四氢-1H-3-苯并氮杂 盐酸盐

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5 MG
$167.00
10 MG
$262.00
25 MG
$701.00
100 MG
$2,310.00

$167.00

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5 MG
$167.00
10 MG
$262.00
25 MG
$701.00
100 MG
$2,310.00

About This Item

经验公式（希尔记法）:
C17H18ClNO · HCl
CAS号:
125941-87-9
分子量:
324.24
MDL编号:
MFCD00069249
UNSPSC代码:
12352200
PubChem化学物质编号:
24277910
NACRES:
NA.77

$167.00

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质量水平

100

方案

≥98% (HPLC)

表单

solid

旋光性

[α]/D +32.1°, c = 1 in DMF(lit.)

储存条件

desiccated
protect from light

颜色

white

溶解性

H2O: >5 mg/mL

SMILES字符串

Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3

InChI

1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChI key

OYCAEWMSOPMASE-XFULWGLBSA-N

基因信息

human ... DRD1(1812)

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应用

R(+)-SCH-23390盐酸盐可用于：
  • 腹腔注射实验大鼠，研究D1受体在致敏性中的作用[1]
  • 作为D1受体选择性拮抗剂，注入颅内药物[2]
  • 作为D1受体拮抗剂，研究其对鱼类学习能力的影响[3]

生化/生理作用

R(+)-SCH-23390盐酸盐是一种选择性D1多巴胺受体拮抗剂。在体外对5-羟色胺2 (5-HT2)和5-HT1C 血清素受体亚型具有更强的结合力。给药后R(+)-SCH-23390的半衰期为25分钟。众所周知，它具有抗定型和促僵硬作用。此外，它还对肌动活动有抑制作用。[4]

特点和优势

受体分类和信号转导手册的多巴胺受体和钾通道页面重点介绍了该化合物。想要浏览手册的其他页面， 请单击此处。

法律信息

经先灵葆雅许可出售。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000338115
0000242277
0000350431
0000242277
0000338115

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Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
SCH 23390: the first selective dopamine D1-like receptor antagonist
Bourne James A
Cns Drug Reviews, 7(4), 399-414 (2001)
A Sidhu et al.
European journal of pharmacology, 128(3), 213-220 (1986-09-09)
[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to specific binding sites (maximum binding = 108 +/- 3.5 fmol/mg) in the caudate nucleus of the rat brain. The caudate binding site displays pharmacological
Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Messias Joao PM, et al.
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)
L C Iorio et al.
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
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Questions

1–7 of 7 Questions  

  1. What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?

    1 answer

    1. The melting point is 247-248°C.

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  2. Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?

    1 answer

    1. Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.

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  3. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  4. How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?

    1 answer

    1. The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.

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  5. Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?

    1 answer

    1. The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.

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  6. What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?

    1 answer

    1. Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.

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  7. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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