C7291

氯米帕明 盐酸盐

≥98% (HPLC), powder

• 别名: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
• 经验公式（希尔记法）: C₁₉H₂₃ClN₂ · HCl
• CAS号: 17321-77-6
• 分子量: 351.31
• EC號碼: 241-344-3
• MDL號碼: MFCD00069234
• 分類程式碼代碼: 12352116
• PubChem物質ID: 24278087
• NACRES: NA.77

属性

• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 溶解度: H₂O: 25 mg/mL; 0.1 M HCl: soluble
• 起源: Novartis
• SMILES 字串: Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
• InChI 密鑰: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• 基因資訊: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

说明

一般說明

Clomipramine hydrochloride is an antiobsessional drug.[1] It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.[2]

應用

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms.[3] It has also been used to study its role on bone mass.[4]

Clomipramine hydrochloride has been used:

• to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques[5]
• to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation[6]
• as a serotonin reuptake inhibitor[7]
• as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor[8]

生化／生理作用

Clomipramine hydrochloride (CLP) is a amphiphilic drug,[5] with two benzene rings in its structure.[9] It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.[5]

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

特點和優勢

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Danger
• 危險聲明: H302,H336,H370,H410
• 防範說明: P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
• 標靶器官: Central nervous system, Central nervous system,Cardiovascular
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves