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Merck

C1115

Sigma-Aldrich

柯胺G

≥95% (HPLC), solid

别名:

4,4′-双(3-羧基-4-羟基苯偶氮)联苯 二钠盐

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About This Item

经验公式(希尔记法):
C26H16N4Na2O6
CAS号:
分子量:
526.41
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供

方案

≥95% (HPLC)

表单

solid

颜色

orange

溶解性

DMSO: ~4 mg/mL

储存温度

−20°C

SMILES字符串

[Na+].[Na+].Oc1ccc(cc1C([O-])=O)N=Nc2ccc(cc2)-c3ccc(cc3)N=Nc4ccc(O)c(c4)C([O-])=O

InChI

1S/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,31-32H,(H,33,34)(H,35,36);;/q;2*+1/p-2

InChI key

AZOPGDOIOXKJRA-UHFFFAOYSA-L

一般描述

柯胺G是一种刚果红羧酸衍生物。[1]

生化/生理作用

β-淀粉样蛋白聚集体的新探针。
柯胺G可以穿过血脑屏障。它可用于阿尔茨海默病′(AD)病理学研究中的脑淀粉样蛋白β (Aβ)沉积的定量测定。[1]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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V Heiser et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(12), 6739-6744 (2000-06-01)
The accumulation of insoluble protein aggregates in intra and perinuclear inclusions is a hallmark of Huntington's disease (HD) and related glutamine-repeat disorders. A central question is whether protein aggregation plays a direct role in the pathogenesis of these neurodegenerative diseases.
Fusheng Yang et al.
The Journal of biological chemistry, 280(7), 5892-5901 (2004-12-14)
Alzheimer's disease (AD) involves amyloid beta (Abeta) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation
W E Klunk et al.
Neurobiology of aging, 16(4), 541-548 (1995-07-01)
Chrysamine-G (CG) is a carboxylic acid analogue of Congo red, a histologic dye which stains amyloid. CG binds to the beta-amyloid protein of Alzheimer's disease (AD) in vitro and partitions into the brain of normal mice. In this study, we
N A Dezutter et al.
European journal of nuclear medicine, 26(11), 1392-1399 (1999-11-07)
Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein (Abeta 10-43) and to homogenates of several regions of the brain of Alzheimer's disease (AD) patients. We synthesised a conjugate of 2-(acetamido)-CG
D L Smith et al.
Neurobiology of disease, 8(6), 1017-1026 (2001-12-14)
Huntington's disease (HD) is a late onset neurodegenerative disorder caused by a CAG/polyglutamine (polyQ) repeat expansion. PolyQ aggregates can be detected in the nuclei and processes of neurons in HD patients and mouse models prior to the onset of symptoms.

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