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Merck
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文件

72335

Sigma-Aldrich

9-(2,2-二氰乙烯基)久洛啶

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

别名:

9-久洛啶基亚甲基丙二腈, DCVJ

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About This Item

经验公式（希尔记法）:
C16H15N3
CAS号:
58293-56-4
分子量:
249.31
Beilstein:
413882
MDL號碼:
MFCD01747392
分類程式碼代碼:
12352108
PubChem物質ID:
57652412
NACRES:
NA.32

產品線

BioReagent

化驗

≥97.0% (HPLC)

形狀

crystals

溶解度

DMSO: soluble
chloroform: soluble

螢光

λex 433 nm; λem 500 nm in 50 mM Tris pH 8.0; 40% glycerol

適合性

suitable for fluorescence

SMILES 字串

N#C\C(=C/c1cc2CCCN3CCCc(c1)c23)C#N

InChI

1S/C16H15N3/c17-10-13(11-18)7-12-8-14-3-1-5-19-6-2-4-15(9-12)16(14)19/h7-9H,1-6H2

InChI 密鑰

LROAUBRDKLVBCP-UHFFFAOYSA-N

包裝

无底玻璃瓶。内容物在插入式融锥内。

其他說明

作为荧光探针，用于结合蛋白质等，通过减少自由旋转来增加量子产率；吸收波长在~450nm处，发射波长在480-505nm处（溶剂dep.）

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Andrea Hawe et al.
Pharmaceutical research, 27(2), 314-326 (2009-12-31)
The aim was to evaluate fluorescent molecular rotors (DCVJ and CCVJ), which are mainly sensitive to viscosity, for the characterization of polysorbate-containing IgG formulations and compare them to the polarity-sensitive dyes ANS, Bis-ANS and Nile Red. IgG formulations with polysorbate
M A Haidekker et al.
American journal of physiology. Heart and circulatory physiology, 278(4), H1401-H1406 (2000-04-06)
Fluid shear stress (FSS) has been shown to be an ubiquitous stimulator of mammalian cell metabolism. Although many of the intracellular signal transduction pathways have been characterized, the primary mechanoreceptor for FSS remains unknown. One hypothesis is that the cytoplasmic
A Bhattacharyya et al.
Indian journal of biochemistry & biophysics, 32(6), 442-446 (1995-12-01)
Di(cyano vinyl)julolidine (DCVJ) is a fluorescent probe which has been used to monitor the local mobility of its binding sites on proteins. It shows a concentration dependence of its emission spectrum in water. At higher DCVJ concentrations, a longer wavelength
A Bhattacharya et al.
Protein science : a publication of the Protein Society, 5(10), 2029-2036 (1996-10-01)
9-(Dicyanovinyl) julolidine (DCVJ) is a fluorescent probe, which binds to a unique site on the tubulin dimer and exhibits different properties that are dependent upon its oligomeric state (Kung & Reed, 1989). DCVJ binds to tubulin, the tubulin-colchicine complex, and
Markus J Schmidt et al.
Journal of biological engineering, 11, 24-24 (2017-08-09)
The molecular rotor 9-(2-Carboxy-2-cyanovinyl)julolidine (CCVJ) is presumed to have a sensitivity towards velocity or shear which is supposed to result in a change in fluorescence quantum yield. Furthermore, a previously reported photoisomeric behavior may contribute to the measured fluorescence intensity
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