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Merck
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文件

55865

Sigma-Aldrich

地高辛NHS酯

≥80% (HPLC)

别名:

ε-（地高辛-3-0-乙酰氨基）己酸N-羟基琥珀酰亚胺酯, 地高辛NHS

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About This Item

经验公式（希尔记法）:
C35H50N2O10
CAS号:
129273-26-3
分子量:
658.78
MDL號碼:
MFCD02093394
分類程式碼代碼:
12352108
PubChem物質ID:
57651557
NACRES:
NA.25

化驗

≥80% (HPLC)

形狀

solid

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)OCC(=O)NCCCCCC(=O)ON6C(=O)CCC6=O

InChI

1S/C35H50N2O10/c1-33-13-11-23(45-20-28(39)36-15-5-3-4-6-31(42)47-37-29(40)9-10-30(37)41)17-22(33)7-8-25-26(33)18-27(38)34(2)24(12-14-35(25,34)44)21-16-32(43)46-19-21/h16,22-27,38,44H,3-15,17-20H2,1-2H3,(H,36,39)/t22-,23+,24-,25-,26+,27-,33+,34+,35+/m1/s1

InChI 密鑰

KHNDABJZSPPYLE-FUGFVFQCSA-N

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應用

地高辛配基NHS酯可用于制备链霉亲和素-地高辛配基偶联物和地高辛重组Ara h1（花生成分）偶联物，用于酶联免疫吸附试验(ELISA)。

生化／生理作用

地高辛配基(Digoxigenin)是一种糖苷配基，是具有药理活性的植物毒素。效力低于地高辛。低剂量可治疗心脏疾病。地高辛配基常与另一种载荷偶联，使其活性降低或更不易进入组织。由于地高辛配基永久性连接载荷并被其完全覆盖，因而无法用作活性基团。
地高辛配基NHS酯是一种活化酯，在温和条件下与氨基反应，将地高辛配基连接蛋白质或5′-氨基取代的寡核苷酸地高辛配基标记用于免疫标记分子，以使用具有高亲和力和特异性的抗地高辛配基抗体进行检测。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE.
Cheng-Ting Tsai et al.
The Journal of allergy and clinical immunology, 141(5), 1901-1904 (2017-12-19)
R Antolovic et al.
European journal of biochemistry, 227(1-2), 61-67 (1995-01-15)
Na+/K(+)-ATPase from pig kidney is inactivated by protein-reactive N-hydroxysuccinimidyl derivatives of digoxigenin. Like digoxigenin, its protein-reactive derivatives N-hydroxysuccinimidyl digoxigenin-3-methylcarbonyl-epsilon-aminocaproate (HDMA), 3-amino-3-deoxydigoxigenin hemisuccinimide succinimidyl ester (ADHS), 3-iodoacetylamino-3-deoxydigoxigenin (IAD) and digoxigenin-3-O-succinyl-[2-(N-maleimido)]ethylamide (DSME) inhibited the sodium pump in the presence of Na+, Mg2+
R Antolovic et al.
The Journal of biological chemistry, 273(26), 16259-16264 (1998-06-20)
Searching for a binding protein in blood, which may be involved in the specific transport of cardiac glycosides to their receptor sites on the sodium pump, we isolated a cardiac glycoside-binding protein (CGBG) of 26 kDa from the globulin fraction
R Antolovic et al.
FEBS letters, 368(1), 169-172 (1995-07-10)
The digoxigenin derivative N-hydroxysuccinimidyl digoxigenin-3-O-methylcarbonyl-epsilon-aminocaproate (HDMA) has been shown to covalently label the ouabain binding site of the Na,K-ATPase epsilon subunit [Antolovic et al. (1995) Eur. J. Biochem. 227, 61-67]. In the present study we observed both, labeling and inactivation
Hazal B Kose et al.
Nature communications, 11(1), 3713-3713 (2020-07-28)
A ring-shaped helicase unwinds DNA during chromosome replication in all organisms. Replicative helicases generally unwind duplex DNA an order of magnitude slower compared to their in vivo replication fork rates. However, the origin of slow DNA unwinding rates by replicative
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