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生物源
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
化驗
>95% (SDS-PAGE)
形狀
lyophilized
分子量
~50 kDa by SDS-PAGE
包裝
pkg of 10 μg
雜質
<0.01 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)
一般說明
编码的鞭毛蛋白丝含有55 kDa单体。
鞭毛蛋白(FliC)是一种亚单位蛋白,它聚合形成细菌鞭毛丝。蛋白质有四个结构域(D0、D1、D2、D3)。
生化/生理作用
它还刺激促炎介质的产生:一氧化氮、白细胞介素1 (IL-1)、IL-6、IL-8和肿瘤坏死因子α。
鞭毛蛋白(FliC)能通过TLR5(toll样受体5)激活先天免疫系统,是一种重要的促炎分子。FliC还诱导抗体的产生,并被CD4+ T细胞鉴定为抗原。
外觀
自PBS冻干。
重構
用100 μL去离子水重组。
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
Mucosal administration of flagellin induces innate immunity in the mouse lung.
Infection and Immunity, 72(11), 6676-6679 (2004)
FliC-specific CD4+ T cell responses are restricted by bacterial regulation of antigen expression.
Journal of Immunology, 174, 7929-7938 (2005)
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted.
Molecular Microbiology, 61, 795-809 (2006)
The Journal of nutrition, 150(10), 2673-2686 (2020-09-05)
Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear. We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 290(1), G96-G108 (2006)
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