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Merck

50838

Sigma-Aldrich

R)-甲羟戊酸 锂盐

≥93.0% (qNMR)

别名:

R-MVA-Li, (R)-3,5-二羟基-3-甲基戊酸锂

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About This Item

经验公式(希尔记法):
C6H11LiO4
分子量:
154.09
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.25

等级

for analytical purposes

方案

≥93.0% (qNMR)

旋光性

[α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h)

储存温度

2-8°C

SMILES字符串

[Li+].C[C@@](O)(CCO)CC([O-])=O

InChI

1S/C6H12O4.Li/c1-6(10,2-3-7)4-5(8)9;/h7,10H,2-4H2,1H3,(H,8,9);/q;+1/p-1/t6-;/m1./s1

InChI key

PVWNXFFXFNEHDZ-FYZOBXCZSA-M

应用

甲羟戊酸可用作分离或检测甲羟戊酸试验中的参考材料。甲羟戊酸是异戊烯焦磷酸(IPP)和甲羟戊酸途径的前体,它可以引导类异戊二烯生物的合成。甲羟戊酸可用作鉴定和表征甲羟戊酸激酶的底物。

生化/生理作用

甲羟戊酸[1][2]是甲羟戊酸途径中的中间体,产生萜烯和类固醇。该功能提供治疗选择为常染色体隐性遗传甲羟戊酸尿症(一种胆固醇和非甾醇异戊二烯生物合成的先天性错误)患者的代谢紊乱[3] [4] [5][6][7][8]、R-甲羟戊酸累积提供了治疗选项[9]

包装

无底玻璃瓶。内含物装在插入的融合锥内。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

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Enantiomerically pure phosphonate analogues of cis- and trans-4-hydroxyprolines.
Cornforth, R. H., et al.
Tetrahedron, 18, 1351-1354 (1962)
A Scoppola et al.
Kidney international, 51(3), 908-912 (1997-03-01)
Mevalonic acid (mevalonate or MVA), is an obligate precursor in the biosynthetic pathway of cholesterol. It is partially metabolized by the kidneys and its plasma concentrations are an index of endogenous cholesterol synthesis. The aim of the present study was
Mutational spectrum and genotype-phenotype correlations in mevalonate kinase deficiency.
Mandey, S. H., et al.
Human Mutation, 27, 796-802 (2006)
Discovery and chemistry of mevalonic acid.
Wagner, A. F. and Folkers, K.
Advances in Enzymology and Related Areas of Molecular Biology, 23, 471-483 (1961)
S M Houten et al.
Cellular and molecular life sciences : CMLS, 60(6), 1118-1134 (2003-07-16)
Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is demonstrated by the identification of

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