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化驗
≥95.0% (HPLC)
應用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES 字串
COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
InChI
1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
InChI 密鑰
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
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一般說明
异鼠李素是一种 O-甲基化黄酮醇，存在于水果、植物和草药中。它是槲皮素的代谢物。
應用
异鼠李素（IRN）可用于：
- 作为神经保护剂，以研究东莨菪碱所致小鼠皮质-海马学习和记忆障碍的影响
- 作为四极杆飞行时间串联质谱法（QTOF MS）的参考标准，以分析并量化蜂蜜提取物中的酚类化合物
- 作为参考标准品，通过反相高效液相色谱法及二极管阵列检测和电喷雾质谱法（RP-HPLC-DAD-ESI-TQ-MS/MS）测定蒿属酚的含量
生化／生理作用
异鼠李素具有抗氧化、抗炎症、抗肿瘤、抗菌和抗病毒的作用。作为一种潜在的神经保护剂，可抑制糖尿病（DM）患者海马结构的神经退行性变。低水平的异鼠李素可以作为一种抗糖尿病药物，促进骨骼肌细胞对葡萄糖的摄取并在高血糖情况下维持血糖稳态。它调节了核因子 kB（NF-κB）、磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶（AKT）、丝裂原活化蛋白激酶（MAPK）等细胞信号通路。异鼠李素对动脉粥样硬化和心血管疾病具有保护和治疗作用。
异鼠李素通过干扰脂肪干细胞的分化来抑制脂肪形成，其机制为稳定 β-连环蛋白和上调 Wnt 信号通路。
包裝
无底玻璃瓶。内含物在插入的融合锥体内。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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