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17304

Sigma-Aldrich

藏花素

for microscopy

别名:

藏红花酸二龙二糖酯

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1 G
$82.90
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About This Item

经验公式（希尔记法）:
C44H64O24
CAS号:
42553-65-1
分子量:
976.96
EC 号:
255-881-6
MDL编号:
MFCD00017495
UNSPSC代码:
12352200
PubChem化学物质编号:
57647630
NACRES:
NA.47

$82.90

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等级

for microscopy

表单

solid

适用性

suitable for microscopy

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

2-8°C

SMILES字符串

CC(=C\C=C\C=C(C)\C=C\C=C(/C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)\C=C\C=C(\C)C(=C)CO[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O

InChI

1S/C46H68O23/c1-21(12-8-14-23(3)25(5)18-62-43-40(59)36(55)32(51)28(67-43)19-63-44-38(57)34(53)30(49)26(16-47)65-44)10-6-7-11-22(2)13-9-15-24(4)42(61)69-46-41(60)37(56)33(52)29(68-46)20-64-45-39(58)35(54)31(50)27(17-48)66-45/h6-15,26-41,43-60H,5,16-20H2,1-4H3/b7-6+,12-8+,13-9+,21-10-,22-11+,23-14-,24-15+/t26-,27-,28-,29-,30-,31-,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,43-,44-,45-,46+/m1/s1

InChI key

LUVDBMJRTUBHNX-RSXXRLSLSA-N

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相关类别

一般描述

一种在藏红花中发现的高度不饱和的二萜二羧酸酯。
藏红花素（CR）是一种水溶性类胡萝卜素，存在于栀子花和藏红花（ Crocus sativus）中。它的结构中有两个 D-龙胆苷糖基酯。CR 是藏红花中主要的生物活性化合物之一，也是藏红花呈现红色的原因。

应用

藏红花素已用于：
  • 作为参比标准品，采用高效液相色谱法检测藏红花提取物中其含量
  • 研究它作为抗氧化和抗炎剂对阿霉素引起的大鼠肾毒性的保护作用
  • 在 SiHa 细胞和雌性 BALB/c 裸鼠上检测其抗肿瘤作用及其促进自噬和凋亡、抑制宫颈癌进展的作用
  • 作为顺铂联合治疗，观察其对顺铂（CIS）引起的大鼠睾丸毒性的保护作用

生化/生理作用

藏红花素具有抗氧化、抗炎症、抗癌、抗变性和抗糖尿病的特性。
藏红花素可缓解乙醇诱导的学习障碍，并阻止乙醇诱导的海马长时程增强 (LTP) 抑制，LTP 是一种可能影响学习和记忆的活性依赖性突触可塑性形式。相关的 CNS 效应是二基因二糖酯特有的；西红花酸葡萄糖龙胆二糖酯的效力是二分之一，二葡萄糖酯则完全没有作用。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCG1963
BCCK6052
BCCD4237
BCCB7407
BCBV9507

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Francesca Gullo et al.
Frontiers in neuroscience, 11, 500-500 (2017-09-22)
Increasing evidence supports a decisive role for neuroinflammation in the neurodegenerative process of several central nervous system (CNS) disorders. Microglia are essential mediators of neuroinflammation and can regulate a broad spectrum of cellular responses by releasing reactive oxygen intermediates, nitric
Mika Masaki et al.
Molecular nutrition & food research, 56(2), 304-308 (2011-11-01)
Crocus sativus L. (saffron) has been traditionally used for the treatment of insomnia and other diseases of the nervous systems. Two carotenoid pigments, crocin and crocetin, are the major components responsible for the various pharmacological activities of C. sativus L.
Amir Faramarzpour et al.
Veterinary research forum : an international quarterly journal, 10(3), 227-234 (2019-11-19)
Crocin, as a carotenoid compound of saffron, exerts a potent antioxidant property. Mesalazine is frequently used in the treatment of ulcerative colitis. This study investigated the effects of separated and combination treatments with crocin and mesalazine in a rat model
Olga Bountagkidou et al.
Journal of chromatography. A, 1237, 80-85 (2012-03-31)
An on-line HPLC (high performance liquid chromatography) method for the rapid screening of individual antioxidants in mixtures was developed using crocin as a substrate (i.e. oxidation probe) and 2,2'-azobis(2-amidinopropane dihydrochloride (AAPH)) in phosphate buffer (pH 7.5) as a radical generator.
R Fogelholm et al.
Journal of neurology, neurosurgery, and psychiatry, 55(12), 1121-1124 (1992-12-01)
Forty one (14.2%) of 288 patients with primary intracerebral haemorrhage occurring between September 1985 and December 1989 in Central Finland were on anticoagulant treatment at the onset of symptoms. In a sample of 29,000 subjects from the same population the
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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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