PHR1732

盐酸万古霉素

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: Vancomycin 盐酸盐
• 经验公式（希尔记法）: C₆₆H₇₅Cl₂N₉O₂₄ · xHCl
• CAS号: 1404-93-9
• 分子量: 1449.25 (free base basis)
• UNSPSC代码: 41116107
• NACRES: NA.24

属性

• 等级: certified reference material; pharmaceutical secondary standard
• 质量水平: 300
• Agency: traceable to Ph. Eur. V0045000; traceable to USP 1709007
• API类: vancomycin
• CofA: current certificate can be downloaded
• 包装: pkg of 4x250 mg
• 技术: HPLC: suitable; gas chromatography (GC): suitable
• 应用: pharmaceutical (small molecule)
• 包装形式: neat
• 储存温度: -10 to -25°C
• SMILES字符串: Clc1c2ccc(c1)[C@H]([C@@H]3NC(=O)[C@H](NC(=O)[C@@H]6NC(=O)[C@@H](NC(=O)[C@@H]([C@@H](c7cc(c(cc7)Oc8c(c(cc6c8)O2)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O[C@@H]%10O[C@H]([C@H]([C@](C%10)(N)C)O)C)O)O)CO)Cl)O)NC(=O)[C@H](NC)CC(C)C)CC(=O)N)c4cc(c(cc4)O)c5c(cc(cc5O)
• InChI: 1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1
• InChI key: LCTORFDMHNKUSG-XTTLPDOESA-N

说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Vancomycin hydrochloride is a glycopeptide antibiotic, effective for the treatment of endocarditis caused by Gram-positive bacteria.[1][2] It is used to inhibit the synthesis of bacterial cell wall and prevents the synthesis of peptidoglycan by binding tightly to peptides containing D-alanyl-D-alanine at the free carboxyl end. It is isolated from both Streotomyces orientalis and Nocardia lurida.[1]

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Vancomycin hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations,[1] pure form and injections preparations[2] using high-performance liquid chromatography technique[1] and spectrophotometric technique.[2]

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0718 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H317,H334
• 预防措施声明: P261 - P280 - P284 - P304 + P340 - P342 + P311
• 危险分类: Resp. Sens. 1 - Skin Sens. 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable