V1130

万古霉素 盐酸盐 来源于东方链霉菌

BioReagent, suitable for plant cell culture

• 经验公式（希尔记法）: C₆₆H₇₅Cl₂N₉O₂₄ · HCl
• CAS号: 1404-93-9
• 分子量: 1485.71
• Beilstein: 3704657
• 分類程式碼代碼: 10171502
• NACRES: NA.72

属性

• 生物源: Streptomyces orientalis
• 產品線: BioReagent
• 形狀: powder
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place.)
• 濃度: ≥900 μg/mg (as vancomycin base)
• 技術: cell culture | plant: suitable
• 顏色: , off-white to brown or White to orange-brown
• 溶解度: H₂O: 50 mg/mL, clear, colorless to dark yellow (and Very Faint Orange to Faint Orange)
• 抗生素活性譜: Gram-positive bacteria
• 應用: agriculture
• 作用方式: cell wall synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]2C[C@](C)(N)[C@@H](O)[C@@H](C)O2.CN[C@H](CC(C)C)C(=O)NC3[C@H](O)c4ccc(Oc5cc6Oc7ccc(cc7Cl)[C@@H](O)[C@H]8NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC3=O)c(c5)c6)c9ccc(O)c(c9)-c%10c(O)cc(O)cc%10[C@@H](NC8=O)C(O)=O)c(Cl)c4
• InChI: 1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1
• InChI 密鑰: LCTORFDMHNKUSG-XTTLPDOESA-N

说明

一般說明

Chemical structure: glycopeptide

Vancomycin is a heptapeptide.

應用

Vancomycin hydrochloride from Streptomyces orientalis has been used as:

• an antibiotic in screening: minimal inhibitory concentrations (MICs) Streptomyces coelicolor
• in treating Leishmania infected sand flies
• in combined antibiotic treatment in asthma induced mice

生化／生理作用

作用机制：它会抑制 NAM/NAG-肽的末端 D-丙氨酰-D-丙氨酸部分插入。

抗菌谱：对革兰氏阳性细菌有活性。

Vancomycin is used for treating methicillin-resistant Staphylococcus aureus (MRSA) infections and shunt-associated Staphylococcal ventriculitis. It may lead to hypersensitivity reactions like anaphylaxis and red man syndrome. Vanomycin is also used to treat thrombocytopenia and induces drug reaction with eosinophilia and systemic symptoms (DRESS) on usage.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H317,H334
• 防範說明: P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
• 危險分類: Resp. Sens. 1 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves