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等级
analytical standard
质量水平
方案
≥98.5% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
杂质
≤1.0% water
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
InChI
1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI key
HPNSFSBZBAHARI-RUDMXATFSA-N
基因信息
human ... IMPDH1(3614) , IMPDH2(3615)
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应用
产自短密青霉的霉酚酸（MPA）是肌苷单磷酸脱氢酶的一种选择性抑制剂，从而能够抑制T和B淋巴细胞中的DNA合成。 它还可作为免疫抑制剂，并在人淋巴和单核细胞系中作为单核细胞分化和诱导的诱导剂。 MPA作为一种选择剂可用于经转染而表达了大肠杆菌黄嘌呤-鸟嘌呤磷酸核糖基转移酶基因的动物细胞，其推荐用量为25μg/mL。
有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。
霉酚酸可作为参考标准品，通过超高效液相色谱联用串联质谱对人体血浆中的分析物进行测定。[2]
生化/生理作用
作用方式：本品通过抑制细胞因子诱导的一氧化氮生成，抑制嘌呤核苷酸的早期生物合成，并作为 IMP 脱氢酶的特异性抑制剂发挥作用。
注意
供应后，本品应在 2-8°C 干燥条件下储存，适当储存时可保持稳定 5 年。
制备说明
麦考酚酸可溶于 50 mg/mL 甲醇，产生无色至淡黄色溶液，以及氯仿、二氯甲烷、乙醇和 1 N 氢氧化钠溶液。复溶后，建议通过 0.22 μm 过滤器灭菌m 孔径过滤器，分装，-20°C 冷冻。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral
靶器官
Immune system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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