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生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
rat
制造商/商品名称
Chemicon®
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... PPP1R9B(84687)
特异性
Spinophilin
免疫原
Synthetic peptide from rat Spinophilin.
应用
Anti-Spinophilin Antibody detects level of Spinophilin & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Neuronal & Glial Markers
Synapse & Synaptic Biology
Neuronal & Glial Markers
Western blot: 0.05 - 0.1 μg/mL using ECL on rat brain lysate. Reacts with a band of ~140 kDa.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
外形
Affinity purified immunoglobulin. Liquid in 0.02M phosphate buffer containing 0.25M NaCl, pH 7.6 with 0.1% sodium azide.
储存及稳定性
Maintain at 2-8°C in undiluted for up to 6 months after date of receipt.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Micah A Shelton et al.
Biological psychiatry, 78(6), 374-385 (2015-03-31)
Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role in maintaining dendritic structure through its interaction with microtubules. In schizophrenia (Sz), numerous studies have revealed that the typically robust immunoreactivity (IR) of MAP2 is significantly reduced across
Zhiping Mi et al.
Neurobiology of aging, 55, 159-166 (2017-03-06)
Precuneus (PreC) cortex is affected with amyloid plaques early in Alzheimer's disease (AD), and this pathology may be associated with alterations in PreC synapses and cognitive impairment. We quantified the spinophilin-immunoreactive (ir) dendritic spine density and the intensity of spinophilin
Eva M Verdugo-Sivianes et al.
Oncotarget, 8(62), 105196-105210 (2017-12-30)
The scaffold protein Spinophilin (Spinophilin, PPP1R9B) is one of the regulatory subunits of phosphatase-1 (PP1), directing it to distinct subcellular locations and targets. The loss of Spinophilin reduces PP1 targeting to pRb, thereby maintaining higher levels of phosphorylated pRb. Spinophilin
Melanie J Grubisha et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(49) (2021-12-02)
Normally, dendritic size is established prior to adolescence and then remains relatively constant into adulthood due to a homeostatic balance between growth and retraction pathways. However, schizophrenia is characterized by accelerated reductions of cerebral cortex gray matter volume and onset
Kisho Obi-Nagata et al.
Science advances, 9(23), eade5973-eade5973 (2023-06-09)
Human genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined the effects of synaptic inputs on dendrites, cells, and behaviors of mice
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