推荐产品
product name
3-异丁基-1-甲基黄嘌呤, A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white
溶解度
ethanol: 10 mg/mL
DMSO: 100 mM
methanol: 50 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChI 密鑰
APIXJSLKIYYUKG-UHFFFAOYSA-N
一般說明
cAMP和cGMP磷酸二酯酶的一种非特异性细胞可渗透抑制剂（IC50 = 2-50 µM）。还可作为一种腺苷受体拮抗剂。已报道可抑制TNFα在脂肪细胞前体细胞中的表达。
cAMP和cGMP磷酸二酯酶的细胞可渗透非特异性抑制剂（IC50 = 2-50 µM）。还可作为一种腺苷受体拮抗剂。已报道可抑制TNF-α在脂肪细胞前体细胞中的表达。
生化／生理作用
主要靶标
cAMP和cGMP磷酸二酯酶
cAMP和cGMP磷酸二酯酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：2-50 µM，靶向cAMP和cGMP磷酸二酯酶
警告
毒性：标准处理（A）
準備報告
可能需要加热才能完全溶解。
重構
在乙醇或甲醇中重溶后，冷藏保存（4°C）。在DMSO中重溶后，等分并冷冻保存（-20°C）。乙醇/甲醇和DMSO储备溶液可分别在4°C或-20°C下稳定保存长达6个月。
其他說明
Hube, F., et al. 1999.Horm.代谢Res.31, 359.
Morgan, A.J., et al. 1993.生物化学。Pharmacol.45, 2373.
Scamps, F., et al. 1993.Eur. J. Pharmacol.244, 119.
Turner, N.C., et al. 1993.Br. J. Pharmacol.108, 876.
Tamura, T., et al. 1991.J. Gen.Physiol.98, 95.
Beavo, J.A., and Reifsnyder, D.H.1990.Trends Pharmacol.Sci.11, 150.
Russell, T.R.1979.Proc.Natl.Acad.Sci. USA76, 4451.
Morgan, A.J., et al. 1993.生物化学。Pharmacol.45, 2373.
Scamps, F., et al. 1993.Eur. J. Pharmacol.244, 119.
Turner, N.C., et al. 1993.Br. J. Pharmacol.108, 876.
Tamura, T., et al. 1991.J. Gen.Physiol.98, 95.
Beavo, J.A., and Reifsnyder, D.H.1990.Trends Pharmacol.Sci.11, 150.
Russell, T.R.1979.Proc.Natl.Acad.Sci. USA76, 4451.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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