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Merck
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主要文件

317240

Sigma-Aldrich

盐酸二甲双胍

≥97% (titration), solid, AMPK signaling activator, Calbiochem®

别名:

盐酸二甲双胍

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About This Item

经验公式（希尔记法）:
C4H11N5 · xHCl
CAS号:
1115-70-4
分子量:
129.16 (free base basis)
MDL编号:
MFCD00012582
UNSPSC代码:
12352200
NACRES:
NA.77
价格与库存信息目前不能提供

产品名称

盐酸二甲双胍, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

质量水平

100

描述

Merck USA index - 14, 5938

方案

≥97% (titration)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 50 mg/mL

运输

ambient

储存温度

10-30°C

SMILES字符串

Cl.N(C)(C)C(=N\C(=N\[H])\N)N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

一般描述

一种通过降低肝脏葡萄糖输出而起作用的抗高血糖药。不会刺激胰岛素分泌，促进体重增加或引起低血糖症。据报道刺激AMP激活的蛋白激酶（AMPK），导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。
一种降低血葡萄糖水平而不刺激胰岛素分泌、促进体重增加或引起低血糖症的抗高血糖药。据报道刺激AMP激活的蛋白激酶（AMPK），导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。

生化/生理作用

主要靶标
AMP激活的蛋白激酶（AMPK）
产物不与ATP竞争。
可逆：否
细胞渗透性：否

包装

用惰性气体包装

警告

毒性：刺激性（B）

重悬

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。

其他说明

Cleasby, M.E., et al. 2004.Diabetes53, 3258.
Klein, J., et al. 2004.J. Endocrinol.183, 299.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000.Nat. Med.6, 998.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Questions

1–2 of 2 Questions  

  1. What is the solubility of Metformin (Cat#317240) in DMSO?

    1 answer

    1. The substance dissolves in DMSO at concentrations of up to 8 mg/ml.

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  2. is metformin accociated with paracitic worms?

    1 answer

    1. There have been studies published regarding the efficacy of Metformin against various parasites. Please see the link below to review one such study of Echinococcisis. Note that this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321462/

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