219556

Ceranib-2

A cell-permeable, potent inhibitor of ceramidase (IC₅₀ = 28 mM) with anti-proliferative and proapoptotic properties.

• 别名: Ceranib-2, Ceranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III
• 经验公式（希尔记法）: C₂₅H₁₉NO₃
• 分子量: 381.42
• MDL號碼: MFCD25977826
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 100 mg/mL, clear, pale yellow
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: O=C(N1)C(C(/C=C/C2=CC=C(OC)C=C2)=O)=C(C3=CC=CC=C3)C4=C1C=CC=C4

说明

一般說明

A cell-permeable, potent inhibitor of ceramidase (IC₅₀ = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC₅₀ = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Draper, J., et al. 2011, Mol. Cancer Ther.10, 2052.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3