204863

Complement iC3b, Human

Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.

• 别名: Complement iC3b, Human Complement iC3b, Human iC3b
• UNSPSC代码: 12352202
• NACRES: NA.25

属性

• 质量水平: 100
• 方案: ≥90% (SDS-PAGE)
• 表单: liquid
• 不包含: preservative
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; avoid repeated freeze/thaw cycles
• 杂质: IgG, IgA, IgM, C5, Factor H, or Factor I, trace
• 运输: wet ice
• 储存温度: −70°C

说明

一般描述

Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.

包装

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

其他说明

Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol.153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol.37, 217.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable