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A-096

Supelco

醛固酮标准液 溶液

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

别名:

醛固酮, 11β，21-二羟基-3，20-二氧代-4-孕-18-烯醛, 11β，21-二羟孕-4-烯-3，18，20-三酮, 18-醛固酮, Reichstein X

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About This Item

经验公式（希尔记法）:
C21H28O5
CAS号:
52-39-1
分子量:
360.44
Beilstein:
3224996
EC號碼:
200-835-2
MDL號碼:
MFCD00051136
分類程式碼代碼:
41116107
PubChem物質ID:
329770641
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

特點

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

100 μg/mL in acetonitrile

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing
clinical testing

格式

single component solution

儲存溫度

−20°C

SMILES 字串

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI 密鑰

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

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相关类别

一般說明

醛固酮是盐皮质激素家族中的一种激素，可刺激钠跨细胞膜转运，并有助于维持血压和血容量。通过LC-MS/MS测量血清/血浆和尿液中的醛固酮水平，以检测从肾上腺皮质继发性醛固酮增多症到肾血管疾病和Bartter综合征的原发性或增生的检查。

應用

醛固酮的D-异构体被认为是具有生物活性的异构体。

其他說明

以醛和半缩醛的平衡混合物形式存在。

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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象形圖

FlameExclamation mark
GHS02,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

35.6 °F - closed cup

閃點（°C）

2 °C - closed cup

分析证书(COA)

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Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved?
Christian Delles et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 958-960 (2013-03-06)
Teresa Duda et al.
Biochemistry, 52(13), 2337-2347 (2013-03-08)
ANF-RGC is the prototype membrane guanylate cyclase, both the receptor and the signal transducer of the hormones ANF and BNP. After binding them at the extracellular domain, it, at its intracellular domain, signals activation of the C-terminal catalytic module and
Ajay D Rao et al.
The American journal of cardiology, 112(1), 73-78 (2013-04-20)
Myocardial extracellular matrix expansion and reduced coronary flow reserve (CFR) occur in patients with type 2 diabetes mellitus without heart failure or coronary artery disease. Because aldosterone is implicated in the pathophysiology of cardiac fibrosis and vascular injury, the aim
Felix Beuschlein
European journal of endocrinology, 168(6), R85-R93 (2013-04-10)
Arterial hypertension is a major cardiovascular risk factor that affects between 10 and 40% of the population in industrialized countries. Primary aldosteronism (PA) is the most common form of secondary hypertension with an estimated prevalence of around 10% in referral
Baojian Xue et al.
Hypertension (Dallas, Tex. : 1979), 61(6), 1255-1262 (2013-04-24)
The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women.
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实验方案

LC/MS/MS Analysis of Steroid Hormones in Plasma

The conversion of clinical methods to LC/MS/MS offers advantages; however, is accompanied by a few limitations, notably interference effects from the endogenous sample matrix.

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