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Merck

A9477

Sigma-Aldrich

醛固酮

≥95% (HPLC), powder

别名:

11β,21-二羟基-3,20-二氧代-4-孕-18-烯醛, 11β,21-二羟孕-4-烯-3,18,20-三酮, 18-醛固酮, Reichstein X

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5 MG
$240.00
25 MG
$553.00
100 MG
$1,620.00

$240.00


预计发货时间2025年1月31日详情


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5 MG
$240.00
25 MG
$553.00
100 MG
$1,620.00

About This Item

经验公式(希尔记法):
C21H28O5
CAS号:
分子量:
360.44
Beilstein:
3224996
EC號碼:
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

$240.00


预计发货时间2025年1月31日详情


获取大包装报价

产品名称

醛固酮, ≥95% (HPLC)

生物源

synthetic (organic)

品質等級

無菌

non-sterile

化驗

≥95% (HPLC)

形狀

powder

技術

cell culture | mammalian: suitable

溶解度

chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI 密鑰

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

基因資訊

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一般說明

醛固酮在盐、钾、血压和酸碱平衡的多因子调节中起着重要作用。它还参与胎儿发育过程中的母体体积扩张,支持胎儿灌注,并可能有助于增加胎盘生长因子的表达。醛固酮的主要活性与肾脏有关,但也可与其他组织(如胃肠道、呼吸道上皮、心肌和血管平滑肌)中的盐皮质激素受体相互作用。[1]醛固酮拮抗剂或盐皮质激素受体拮抗剂 (MRA) 可使各种临床疾病患者受益,包括原发性醛固酮增多症 (PA)、原发性和难治性高血压、心力衰竭 (HF) 和慢性肾病 (CKD)。[2]

應用

醛固酮已被用于:
  • 作为足细胞培养的RPMI-1640培养基补充,以测试其在肥胖相关肾小球病(ORG)中的致病性[3]
  • 结合盐诱导小鼠肾损伤[4]
  • 刺激原发性肝窦内皮细胞(LSEC)和小鼠醛固酮增多症模型的产生[5]

醛固酮的D-异构体被认为是具有生物活性的异构体。

生化/生理作用

醛固酮是一种具有生物活性的醛固酮异构体;肾上腺激素由肾上腺皮质产生的一种矿物质皮质激素。它可以诱导尿中K+排出,肾中Na+再吸收。[6]它由促肾上腺皮质激素(ACTH)产生,对维持远端小管的钠稳态至关重要。[7]醛固酮结合到矿糖皮质激素受体,可调节血管系统和诱导肾损害。[8]它有助于慢性肾脏疾病(CKD)的进展。[4]醛固酮是肾素-血管紧张素-醛固酮系统(RAAS)的一部分。[5]

其他說明

以醛和半缩醛的平衡混合物形式存在。

相關產品

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Aldosterone receptor antagonists: current perspectives and therapies
Guichard JL, et al.
The Journal of biological chemistry, 321-331 (2013)
Physiology, Aldosterone
Scott, JH, et al.
StatPearls [Internet] (2023)
Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone-and salt-induced renal injury
Hisamichi M
Hypertension Research, 41(1), 8-8 (2018)
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Luo X, et al.
Redox Biology, 13(5), 508-521 (2017)
Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology
Cannavo A, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)

Questions

1–5 of 5 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. Is Product A9477, Aldosterone, the d- or l- isomer?

    1 answer
    1. The A9477 is the d-Aldosterone (per our supplier), which is considered to be the biologically active isomer.

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  3. Is Product A9477, Aldosterone, tested for solubility?

    1 answer
    1. Yes, A9477 is tested for solubility using 20mg/ml in chloroform. For biological applications, you can solubilize aldosterone in ethanol to at least 1 mg/mL. Please refer to literature references for further solubility information.

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  4. What is the difference between Aldosterone Products A9477 and 05521?

    1 answer
    1. The main differences between A9477 and 05521 are the assays performed on the products. The assay results are lot specific and can be viewed on the Certificate of Analysis.

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  5. How do I make a stock solution of Product A9477, Aldosterone?

    1 answer
    1. To prepare a 100 μg/ml stock solution, add 5 ml of absolute ethanol to 5 mg, gently swirl to dissolve, then add 45 ml sterile medium. Freeze the stock in working aliquots, but avoid repeated freeze/thaw cycles.

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