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Merck

N5893

Sigma-Aldrich

(±)-柚皮素

≥95%

别名:

(±)-2,3-二氢-5,7-二羟基-2-(4-羟基苯基)-4H-1-苯并吡喃-4-酮, 4′,5,7-三羟基黄烷酮

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1 G
$105.00
5 G
$190.00
25 G
$350.00

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1 G
$105.00
5 G
$190.00
25 G
$350.00

About This Item

经验公式(希尔记法):
C15H12O5
CAS号:
分子量:
272.25
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

$105.00


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方案

≥95%

表单

powder

mp

247-250 °C (lit.)

SMILES字符串

OC1=CC=C(C=C1)C(C2)OC3=CC(O)=CC(O)=C3C2=O

InChI

1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2

InChI key

FTVWIRXFELQLPI-UHFFFAOYSA-N

基因信息

human ... CYP1A2(1544)

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应用

(±)-柚皮素是一种多酚材料,可用于制备镍(II)柚皮素-肟配合物,该配合物可作为催化剂用于Mizoroki−Heck交叉偶联反应。[1]它已用作次氯酸盐清除剂,以防止人血清白蛋白中次氯酸盐氧化形成氯胺。[2]它可诱导人胰腺癌SNU-213细胞的凋亡。[3]它还显示出对多种人类癌细胞(如乳腺癌、宫颈癌、胃癌、结肠癌和肝癌细胞)的细胞毒性作用。[4]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Krista A Power et al.
Molecular nutrition & food research, 60(11), 2396-2412 (2016-06-29)
This study investigated the effects of cooked whole asparagus (ASP) versus its equivalent level of purified flavonoid glycoside, rutin (RUT), on dextran sodium sulfate (DSS)-induced colitis and subsequent colitis recovery in mice. C57BL/6 male mice were fed an AIN-93G basal
Amy C Burke et al.
Journal of lipid research, 59(9), 1714-1728 (2018-07-17)
Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success in reversing existing obesity and metabolic dysregulation. Previous prevention studies demonstrated that
Hypochlorite scavenging activity of flavonoids
Firuzi O, et al.
The Journal of Pharmacy and Pharmacology, 56(6), 801-807 (2004)
Efficient nickel (ii) naringenin-oxime complex catalyzed Mizoroki-Heck cross-coupling reaction in the presence of hydrazine hydrate
Song JY, et al.
New. J. Chem., 41(20), 12288-12292 (2017)
Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells
Park HJ, et al.
Food And Chemical Toxicology, 99(6), 1-8 (2017)

商品

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子(如铁、铜和镉)引起的氧化损伤。

Questions

1–3 of 3 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. I need to know what is the solubility of naringenin in DMSO before buying? And what is the half life and stability? Can I store the solution or I should to prepare it daily? 

    1 answer
    1. The solubility in DMSO is not tested internally, but literature indicates that it may be soluble up to 50 mg/mL. Solution stability is not tested, so it would be best to prepare a fresh solution as needed. There is no internal information regarding half life.

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