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Merck

D198501

Sigma-Aldrich

2,4-二硝基酚

moistened with water, ≥98.0%

别名:

α-二硝基酚, 2,4-DNP, DNP

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国内现货,预计发货时间2025年4月21日详情


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5 G
$72.30
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About This Item

线性分子式:
(O2N)2C6H3OH
CAS号:
分子量:
184.11
Beilstein:
1246142
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

$72.30


国内现货,预计发货时间2025年4月21日详情


获取大包装报价

蒸汽密度

6.35 (vs air)

质量水平

方案

≥98.0%

包含

≥15% water

mp

108-112 °C (lit.)

SMILES字符串

Oc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H

InChI key

UFBJCMHMOXMLKC-UHFFFAOYSA-N

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应用

2,4-二硝基苯酚(DNP)可用于:
  • 作为催化还原反应的反应物。[1][2]
  • 通过将羧酸转化为二硝基苯基(DNP)酯来激活羧酸。[3]
  • 通过三氟甲磺酸铪催化异丁酸酐发生酰化反应制备相应的酯。[4]
  • 作为有效的助催化剂,可提高天然伯氨基酸衍生的伯胺有机催化剂的活性和对映选择性,从而直接进行不对称的醇醛缩合反应。[5]
  • 作为亚磷酰胺与核苷反应中四唑类的替代活化剂。[6]

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Acute 1 - Desen. Expl. 4 - STOT RE 1

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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2, 4-Dinitrophenol: a novel activating reagent in nucleotide synthesis via the phosphoramidite route. Design of new effective phosphitylating reagents.
Dabkowski W, et al.
Tetrahedron Letters, 41(39), 7535-7539 (2000)
Hafnium inspired activation of highly hindered anhydrides in the acylation of alcohols and polyols.
Mensah E, et al.
Tetrahedron Letters, 59(12), 1094-1098 (2018)
Synthesis and stereochemical assignment of geraniol-and nerol-derived Cygerol enantiomers.
Sukhanova A A, et al.
Tetrahedron Asymmetry, 28(12), 1834-1841 (2017)
Chemical-hydrothermal synthesis of oval-shaped graphene/ZnO quantum hybrids and their photocatalytic performances.
Van T D, et al.
Catalysis Communications, 101, 102-106 (2017)
2, 4-Dinitrophenol as an effective cocatalyst: greatly improving the activities and enantioselectivities of primary amine organocatalysts for asymmetric aldol reactions.
Da C S, et al.
The Journal of Organic Chemistry, 74(6), 2541-2546 (2009)

商品

氧化应激,在一部分上,是由多种细胞过程产生的活性氧介导,并由诸如酶清除剂或抗氧化剂调节剂等细胞抗氧化剂机制所控制的。自由基,如活性氧,会通过细胞引起细胞损伤。

Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

相关内容

Separation of 2-Chlorophenol; 2,4-Dichlorophenol; 2,4,6-Tribromophenol; 2,4,6-Trichlorophenol; 2,4-Dinitrophenol; Pentafluorophenol; 2-Methylphenol, analytical standard; 2,3,4,6-Tetrachlorophenol; Pentachlorophenol; 4-Nitrophenol; 2-Bromophenol; 2,3,5,6-Tetrachlorophenol; 2,3,5-Trichlorophenol; 4-Chloro-3-methylphenol; 2,4,5-Trichlorophenol; 4-Methylphenol, analytical standard; 2,4-Dimethylphenol; 2-Nitrophenol; 3-Methylphenol, analytical standard; Phenol; 2-Methyl-4,6-dinitrophenol; 2,3,4-Trichlorophenol; 2,6-Dichlorophenol; 2,3,4,5-Tetrachlorophenol

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to dissolve D198501?

    1 answer
    1. 2,4-DNP (2,4-dinitrophenylhydrazine) is sparingly soluble in water. To prepare a 0.1M solution of 2,4-DNP (e.g., 500 ml), follow the steps below:
      1. Weigh 9.2 grams of 2,4-DNP and add it to 500 ml of distilled water.
      2. Place the solution on a magnetic stirrer and begin stirring. Note that 2,4-DNP is insoluble in water.
      3. Carefully add solid Tris Base to the solution while stirring until completely dissolved. Typically, 6-8 grams of Tris is sufficient for dissolution.
      4. This process will result in a clear, yellow solution. If necessary, the solution can be filtered.

      Helpful?

  4. Is there any recommended shelf-life or re-test date/period for DNP (D198501)?

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment.

      For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

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