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Merck

55452

Sigma-Aldrich

D-α-羟基异戊酸

≥98.0% (T)

别名:

(R)-2-羟基-3-甲基丁酸

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1 G
$349.00
5 G
$1,320.00

About This Item

经验公式(希尔记法):
C5H10O3
CAS号:
分子量:
118.13
Beilstein:
1721139
MDL编号:
UNSPSC代码:
51113400
PubChem化学物质编号:
NACRES:
NA.22

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方案

≥98.0% (T)

表单

solid

旋光性

[α]20/D −17±1°, c = 1% in chloroform

mp

64-67 °C

官能团

carboxylic acid
hydroxyl

SMILES字符串

CC(C)[C@@H](O)C(O)=O

InChI

1S/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)/t4-/m1/s1

InChI key

NGEWQZIDQIYUNV-SCSAIBSYSA-N

应用

D-α-Hydroxyisovaleric acid may be used in the preparation of biodegradable, optically active and isotactic poly(D-2-hydroxy-3-methylbutanoic acid).[1]

其他说明

该手性 α-羟基酸用于合成肽和缩酚酸肽。[2] 还可用作手性结构单元。[3] 通过二氧戊环酮中间体合成 α-取代 α-羟基酸。[4][5]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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R L Johnson
Journal of medicinal chemistry, 23(6), 666-669 (1980-06-01)
The following N-(alpha-hydroxylakanoyl) derivatives of Leu-Val-Phe-OCH3 were synthesized and tested for their ability to inhibit human amniotic renin: D- and L-alpha-hydroxyisocaproyl-Leu-Val-Phe-OCH3, D- and L-alpha-hydroxyisovaleryl-Leu-Val-Phe-OCH3, L-2-hydroxy-3-phenylpropanoyl-Leu-Val-Phe-OCH3, and D- and L-alpha-hydroxyphenylacetyl-Leu-Val-Phe-OCH3. Analysis of the compounds through the use of Dixion plots showed
W. Hartwig et al.
Liebigs Ann. Chem., 1952-1952 (1982)
Hetero-stereocomplex formation between substituted poly (lactic acid) s with linear and branched side chains, poly (l-2-hydroxybutanoic acid) and poly (d-2-hydroxy-3-methylbutanoic acid).
Tsuji H and Hayakawa T.
Polymer, 55(3), 721-726 (2014)
H.-O. Kim et al.
The Journal of Organic Chemistry, 52, 4531-4531 (1987)
Identification of 3-hydroxyisovalerylcarnitine in the urine of a patient with multiple carboxylase deficiency.
T Nakanishi et al.
Annals of clinical biochemistry, 30 ( Pt 3), 318-320 (1993-05-01)

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