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Merck

347795

Sigma-Aldrich

二氯乙酸钠

98%

别名:

二氯乙酸 钠盐

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10 G
$115.00
50 G
$367.00

About This Item

线性分子式:
Cl2CHCO2Na
CAS号:
分子量:
150.92
EC 号:
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.22

$115.00


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质量水平

方案

98%

杂质

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

官能团

chloro

SMILES字符串

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChI key

LUPNKHXLFSSUGS-UHFFFAOYSA-M

相关类别

一般描述

二氯乙酸钠是一种线粒体丙酮酸脱氢酶激酶(PDK)抑制剂,具有强大的抗白血病活性。[1][2][3]

应用

二氯乙酸钠可用作合成微孔碳的有机盐前体,其可用于开发碳基吸附剂。[4]

象形图

Health hazardExclamation mark

警示用语:

Warning

危险分类

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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本页面介绍了一篇有关瓦博格效应的文章,以及其如何能够在正常氧气水平下,增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明,癌细胞显示出对糖酵解的依赖性增加,以满足他们的能量需求,无论是否有充足的氧气存在。

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Is the product sterile and readily soluble in other solution for intravenous use in medical research?

    1 answer
    1. Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals. For research purposes, in animal models or in vitro assays, the prepared solution would require filter sterilization.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. I have heard that dichloroacetate has been used for cancer treatment.  Is Product 347795, Sodium dichloroacetate, the same chemical?

    1 answer
    1. Some research studies on the use of dichloroacetate as an anti-cancer agent have been performed.  At this time, no dichloroacetate compound or product has been approved for use as an anti-cancer drug.  The common salts of dichloroacetate are sodium and potassium, and these are what have been used in the research studies.  The Sigma-Aldrich products 347795, Sodium Dichloroacetate, and 348082, Potassium Dichloroacetate, are offered for laboratory use only, and are not manufactured or intended for human use.

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  6. How can I make a solution of Product 347795, Sodium dichloroacetate?

    1 answer
    1. Sodium dichloroacetate is soluble in water at 50 mg/ml.

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