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Merck

320129

Sigma-Aldrich

乙酰氯

reagent grade, 98%

别名:

Acetic acid chloride, Acetic chloride, Ethanoyl chloride

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1 KG
$228.00

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国内现货,预计发货时间2025年4月25日详情


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1 KG
$228.00

About This Item

线性分子式:
CH3COCl
CAS号:
分子量:
78.50
Beilstein:
605303
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

$228.00


国内现货,预计发货时间2025年4月25日详情


获取大包装报价

等级

reagent grade

质量水平

蒸汽密度

2.7 (vs air)

蒸汽压

11.69 psi ( 20 °C)
32.33 psi ( 55 °C)

方案

98%

表单

liquid

自燃温度

1353 °F

expl. lim.

19 %

折射率

n20/D 1.389 (lit.)

沸点

52 °C (lit.)

mp

−112 °C (lit.)

密度

1.104 g/mL at 25 °C (lit.)

官能团

acyl chloride

SMILES字符串

CC(Cl)=O

InChI

1S/C2H3ClO/c1-2(3)4/h1H3

InChI key

WETWJCDKMRHUPV-UHFFFAOYSA-N

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一般描述

乙酰氯可通过与十氢化萘和三氯化铝进行反应,得到三环烯醇醚。[1]在Zn粉和氯化铜的存在下,它可促进烯烃与二溴甲烷或二碘甲烷的环丙烷化反应。[2]在离子液体1-丁基-3-甲基咪唑氯化物中,在MCl3(M = Al或Fe)存在下,乙酰氯与苯的Friedel-Crafts反应可得到乙酰氯的MCl3加合物、乙酰鎓离子[CH3CO] + [MCl4]- 、和苯乙酮的MCl3加合物。[3]

应用

  • 抑制真黑素生成的半胱氨酸噻唑烷衍生物的合成、表征和评估。:该研究讨论了半胱氨酸噻唑烷衍生物的合成、表征和评估,其中乙酰氯被用作反应试剂,突出了其在药物中间体开发的重要性。(Amino et al., 2016)。
  • 具有显著稳定性和酸碱催化性质的新URJC-1材料。:该研究介绍了新型URJC-1材料,指出了其稳定性和催化性质,以及乙酰氯是合成过程中的关键物质,阐明了其在材料科学和催化中的作用。(Leo et al., 2016)。

象形图

FlameCorrosion

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

补充剂危害

储存分类代码

3 - Flammable liquids

WGK

WGK 1

闪点(°F)

41.0 °F - closed cup

闪点(°C)

5 °C - closed cup


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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其他客户在看

Ran Lin et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(45), 14885-14899 (2014-09-16)
Treatment of Na[Re(CO)5 ] with RCCCO2 Et (R=phenyl, naphthalen-1-yl, phenanthren-9-yl and pyren-1-yl) followed by reaction with acetyl chloride and ethanol afforded the rhenacyclobutadienes Re{-C(R)C(CO2 Et)C(OEt)}(CO)4 . Reactions of these rhenacyclobutadienes with HCCOEt produced rhenabenzenes Re{-C(R)C(CO2 Et)C(OEt)CHC(OEt)}(CO)4 . Except for R=Ph
Oxetanes. VII. Synthesis from 1, 3-Diols. Reactions of Oxetanes and of 1, 3-Butanediol with Hydrogen Chloride, Hydrogen Bromide and Acetyl Chloride1, 2.
Searles JS, et al.
Journal of the American Chemical Society, 79(4), 952-956 (1957)
In situ infrared spectroscopic studies of the Friedel-Crafts acetylation of benzene in ionic liquids using AlCl3 and FeCl3.
Csihony S, et al.
Green Chemistry, 3(6), 307-309 (2001)
Acetyl chloride promoted cyclopropanations of alkenes with dibromomethane using zinc dust and copper (I) chloride in ether.
Friedrich EC and Lewis EJ.
The Journal of Organic Chemistry, 55(8), 2491-2494 (1990)
Facile catalyzed acylation of alcohols, phenols, amines and thiols based on ZrOCl 2? 8H 2 O and acetyl chloride in solution and in solvent-free conditions.
Ghosh R, et al.
Tetrahedron Letters, 46(1), 147-151 (2005)

商品

Friedel-Crafts acylation with Lewis acid catalysts forms monoacylated products via electrophilic aromatic substitution of arenes.

傅-克酰基化反应是一种芳烃与酰氯或酸酐使用强路易斯酸催化剂的反应。该反应通过亲电芳族取代进行,形成单酰化产物。

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Is this chemical react with eppendorf tubes? Especially when heated?

    1 answer
    1. The most stable materials for use with Acetyl Chloride are FEP and PVDF. Fluoroethylenepropylene (FEP) is not recommended for high heat conditions. While the product number has not been provided, most Eppendorf tubes are polypropylene. Polypropylene is not compatible with this Acetyl Chloride.

      Further information may be available from our Technical Service team who can assist you further. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquires" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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