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Merck

283746

Sigma-Aldrich

4-(氨甲基)苯甲酸

97%, for peptide synthesis

别名:

PAMBA

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About This Item

线性分子式:
H2NCH2C6H4CO2H
CAS号:
分子量:
151.16
Beilstein:
1100606
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.22

product name

4-(氨甲基)苯甲酸, 97%

化驗

97%

形狀

powder

反應適用性

reaction type: solution phase peptide synthesis

mp

≥300 °C (lit.)

應用

peptide synthesis

SMILES 字串

NCc1ccc(cc1)C(O)=O

InChI

1S/C8H9NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5,9H2,(H,10,11)

InChI 密鑰

QCTBMLYLENLHLA-UHFFFAOYSA-N

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應用

4-(氨基甲基)苯甲酸(PAMBA)可用于合成:
  • 钴羧酸膦酸酯。
  • Apoptozole(Az),具有促进突变囊性纤维化跨膜传导调节因子(CFTR)氯通道活性的膜运输的细胞效力。
  • 环肽,由 L-谷氨酸和 3-氨基苯甲酸组成,可用作各种阳离子和阴离子的受体。
  • 生物活性肽,具有有效的 GPR54(G 蛋白偶联受体)激动活性。

其他說明

4-(氨基甲基)苯甲酸也是一种抗出血剂,用于治疗内出血。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Shingo Nakajima et al.
Molecular nutrition & food research, 56(5), 753-760 (2012-06-01)
Dietary peptides are potent stimulators of cholecystokinin (CCK) secretion, but the sensing mechanism in CCK-producing cells is poorly understood. Recently, it has been demonstrated that the calcium-sensing receptor (CaSR) mediates CCK secretion induced by amino acids. We investigated the role
Fmoc?based solid?phase synthesis of GPR54?agonistic pentapeptide derivatives containing alkene?and fluoroalkene?dipeptide isosteres.
Tomita K, et al.
Pept. Sci., 88(2), 272-278 (2007)
Marcus Tirado et al.
Journal of the American Society for Mass Spectrometry, 23(3), 475-482 (2012-01-06)
While recent studies have shown that for some peptides, such as oligoglycines and Leu-enkephalin, mid-sized b fragment ions exist as a mixture of oxazolone and macrocycle structures, other primary structure motifs, such as QWFGLM, are shown to exclusively give rise
Large increase in cation binding affinity of artificial cyclopeptide receptors by an allosteric effect.
Kubik S.
Journal of the American Chemical Society, 121(25), 5846-5855 (1999)
Synthesis of model glycolipids having two long alkyl chains.
Z Zhang et al.
Carbohydrate research, 277(2), C1-C3 (1995-11-22)

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