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Merck

158194

Sigma-Aldrich

2,2′-二硫双(5-硝基吡啶)

96%

别名:

DTNP, 双(5-硝基-2-吡啶基)二硫化物

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1 G
$99.00
10 G
$500.00

About This Item

经验公式(希尔记法):
C10H6N4O4S2
CAS号:
分子量:
310.31
Beilstein:
305413
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

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化驗

96%

形狀

solid

mp

155-157 °C (lit.)

官能基

disulfide
nitro

SMILES 字串

[O-][N+](=O)c1ccc(SSc2ccc(cn2)[N+]([O-])=O)nc1

InChI

1S/C10H6N4O4S2/c15-13(16)7-1-3-9(11-5-7)19-20-10-4-2-8(6-12-10)14(17)18/h1-6H

InChI 密鑰

ROUFCTKIILEETD-UHFFFAOYSA-N

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一般說明

2,2'-二硫代双(5-硝基吡啶)是芳香族二硫化物。[1]

應用

使用 2,2'-二硫代(5-硝基吡啶):
  • 用半胱氨酸活化试剂研究 G 蛋白偶联受体的核磁共振波谱[2]
  • 在用于受保护的含硒代半胱氨酸的肽的去保护测定中[3]
  • 对半胱氨酸和硒代半胱氨酸侧链上的 p -甲氧基苄基和乙酰胺甲基进行脱保护[1]
  • 从半胱氨酸和硒代半胱氨酸侧链中去除 p -甲氧基苄基保护基[1]

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Katharine M Harris et al.
Journal of peptide science : an official publication of the European Peptide Society, 13(2), 81-93 (2006-10-13)
We present here a simple method for deprotecting p-methoxybenzyl groups and acetamidomethyl groups from the side-chains of cysteine and selenocysteine. This method uses the highly elecrophilic, aromatic disulfides 2,2'-dithiobis(5-nitropyridine) (DTNP) and 2,2'-dithiodipyridine (DTP) dissolved in TFA to effect removal of
Uncoupling and energy transfer inhibition of photophosphorylation by sulfhydryl reagents.
J V Moroney et al.
The Journal of biological chemistry, 255(14), 6670-6674 (1980-07-25)
Effects of oxidants on membrane potential, K+ and Ca2+ currents of mouse pancreatic B-cells.
P Krippeit-Drews et al.
Advances in experimental medicine and biology, 426, 355-359 (1997-01-01)
Yu Qi et al.
Nature communications, 11(1), 1262-1262 (2020-03-11)
Binding of biomolecules to crystal surfaces is critical for effective biological applications of crystalline nanomaterials. Here, we present the modulation of exposed crystal facets as a feasible approach to enhance specific nanocrystal-biomolecule associations for improving cellular targeting and nanomaterial uptake.
Chi-Pan Hsieh
Biochemical and biophysical research communications, 370(3), 445-449 (2008-04-01)
Redox modulation of fast inactivation has been described in certain cloned A-type voltage-gated K(+) (Kv) channels in expressing systems, but the effects remain to be demonstrated in native neurons. In this study, we examined the effects of cysteine-specific redox agents

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