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About This Item
线性分子式:
ClC6H3(NO2)CN
CAS号:
分子量:
182.56
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
推荐产品
品質等級
化驗
99%
形狀
powder
mp
105-107 °C (lit.)
SMILES 字串
[O-][N+](=O)c1ccc(Cl)c(c1)C#N
InChI
1S/C7H3ClN2O2/c8-7-2-1-6(10(11)12)3-5(7)4-9/h1-3H
InChI 密鑰
ZGILLTVEEBNDOB-UHFFFAOYSA-N
一般說明
2-Chloro-5-nitrobenzonitrile effectively conjugates with rat glutathione S-transferase (GST) isoenzymes and is an alternative model substrate in GST-research.
應用
2-Chloro-5-nitrobenzonitrile was used in online detection of rat glutathione S-transferase P1-specific inhibitors by high-resolution screening technology.
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
E M van der Aar et al.
Xenobiotica; the fate of foreign compounds in biological systems, 26(2), 143-155 (1996-02-01)
1. Four different rat glutathione S-transferase (GST) isoenzymes, belonging to three different classes, were examined for their GSH conjugating capacity towards 11 2-substituted 1-chloro-4-nitrobenzene derivatives. Significant differences were found in their enzyme kinetic parameters Km, kcat and kcat/Km. 2. Substrates
Jeroen Kool et al.
Journal of biomolecular screening, 12(3), 396-405 (2007-03-24)
A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (cGSTs) and purified human GST P1 to gradient reversed-phase high-performance liquid chromatography (HPLC). The cGSTs and
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